Zhou Bin, Gentry Adrienne, Xu Qian, Young Jamie L, Yan Xiaofang, Pagidas Kelly, Yang Yu, Watson Walter H, Kong Maiying, Cai Lu, Freedman Jonathan H
Pediatric Research Institute, Department of Pediatrics, University of Louisville School of Medicine, USA.
The Affiliated Children's Hospital of Nanchang University, Department of Endocrinology, Metabolism, and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China.
Toxicol Rep. 2021 Mar 20;8:718-723. doi: 10.1016/j.toxrep.2021.03.016. eCollection 2021.
The effects of exposure to the environmental toxicant cadmium, in combination with obesity, on the metal content in mouse testis were evaluated. Starting in utero and continuing through to 10 or 24 weeks post-weaning, male mice were exposed to cadmium (0, 0.5 or 5 ppm), and fed either a low (LFD) or high fat diet (HFD) post-weaning. Testicular levels of cadmium and essential metals were determined 10 and 24 weeks post-weaning by ICP-MS. Similar to what has been previously observed in the liver, kidney, heart and brain, significant levels of cadmium accumulated in the testis under all exposure conditions. Additionally, HFD-fed animals accumulated more cadmium than did their LFD-treated counterparts. Both treatments affected essential metal homeostasis in the testis. These findings suggest that cadmium and obesity may compromise the reproductive potential in the male mouse by disrupting essential metal levels.
评估了环境毒物镉与肥胖共同作用对小鼠睾丸金属含量的影响。从子宫内开始并持续到断奶后10周或24周，雄性小鼠暴露于镉（0、0.5或5 ppm），断奶后喂食低脂肪饮食（LFD）或高脂肪饮食（HFD）。在断奶后10周和24周通过电感耦合等离子体质谱法（ICP-MS）测定睾丸中的镉和必需金属水平。与先前在肝脏、肾脏、心脏和大脑中观察到的情况类似，在所有暴露条件下，睾丸中都积累了大量的镉。此外，喂食HFD的动物比喂食LFD的动物积累了更多的镉。两种处理都影响了睾丸中必需金属的稳态。这些发现表明，镉和肥胖可能通过破坏必需金属水平来损害雄性小鼠的生殖潜力。
