Wehnert J, Sage S
Klinik für Urologie, Medizinischen Akademie Carl Gustav Carus Dresden.
Z Urol Nephrol. 1988 Mar;81(3):153-8.
The influence of phenoxybenzamine on micturition was examined in 46 patients with functional bladder neck obstruction. Due to blockade of the alpha-adrenergic receptors at the bladder neck an increase of the maximal flow rate from a mean value of 13.6 to 24.6 ml s-1 was found during the treatment. In addition, there was a relaxation of the functional urethral length and a reduction of the maximal urethral closure pressure from 96.3 to 74.4 cm H2O. The most significant changes resulting from the application of Dibenzyran were observed in the neuropathic bladder with a reduction of the functional urethral length from 24.3 to 20.5 mm and a decrease of Pura max from 100.5 to 82.7 cm H2O. Furthermore, we achieved an increase of the maximal flow rate from 13.4 to 22.5 ml s-1.
对46例功能性膀胱颈梗阻患者研究了酚苄明对排尿的影响。由于膀胱颈处α-肾上腺素能受体被阻断，治疗期间最大尿流率从平均13.6ml/s增加到24.6ml/s。此外，功能性尿道长度松弛，最大尿道闭合压从96.3cmH₂O降至74.4cmH₂O。应用双苄胺后最显著的变化见于神经源性膀胱，功能性尿道长度从24.3mm减至20.5mm，最大尿道闭合压从100.5cmH₂O降至82.7cmH₂O。此外，我们使最大尿流率从13.4ml/s增加到22.5ml/s。
