Norlén L, Sundin T
Acta Pharmacol Toxicol (Copenh). 1978;43 Suppl 2:31-4. doi: 10.1111/j.1600-0773.1978.tb03216.x.
The effect of alpha-adrenolytic treatment (phenoxybenzamine) was studied in 8 patients with lower motor neuron lesions (autonomous bladders). In the cystometrograms, the bladders were more hypotonic and the "autononous waves" appeared at a higher level of filling or were totally extinguished after this pharmacological treatment. With an isotonic volume registration method, a bladder volume increase was recorded after alpha-adrenergic blockage. Using spincterometry or urethral pressure profile studies, a decrease in the urethral resistance was observed after alpha-adrenolytic treatment, resulting in a decrease in residual urine. This decrease in bladder wall tension and in residual urine effected an increased functional bladder capacity in patients with autonomous bladders.
对8例下运动神经元损伤（自主性膀胱）患者进行了α-肾上腺素能阻滞剂治疗（酚苄明）的效果研究。在膀胱压力容积图中，膀胱张力降低，“自主性波”在更高的充盈水平出现，或在这种药物治疗后完全消失。采用等渗容量记录法，α-肾上腺素能阻断后记录到膀胱容量增加。使用括约肌测压法或尿道压力分布研究，α-肾上腺素能阻滞剂治疗后观察到尿道阻力降低，残余尿量减少。膀胱壁张力和残余尿量的减少使自主性膀胱患者的功能性膀胱容量增加。
