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吉特林综合征下的剖宫产术

[Sectio Caesarea under Gitelman Syndrome].

作者信息

Rombach Stephan, Benner Alexander, Schick Martin Alexander

机构信息

Department of Anesthesiology and Critical Care Medical Center, University of Freiburg, Freiburg, Germany.

Faculty of Medicine, University of Freiburg, Freiburg, Germany.

出版信息

Anasthesiol Intensivmed Notfallmed Schmerzther. 2021 Apr;56(4):289-295. doi: 10.1055/a-1299-0579. Epub 2021 Apr 22.

Abstract

Gitelman syndrome is a rare inherited renal tubulopathy characterized by hypokalemia, hypomagnesemia and metabolic alcalosis. It is caused by a mutation in the gene leading to a dysfunction of the thiazide-sensitive sodium chloride cotransporter and the magnesium transporters in the distal convoluted tubules. Only few reports of pregnant woman with Gitelman syndrome exist. Due to many unsolved questions about the impact on pregnancy and the maternal and fetal outcome, the obstetric and anesthesiological management remains a challenge. We discuss the case of a primary cesarean delivery in a 22-year-old woman with a new diagnosed Gitelman syndrome focusing on the anesthesiological approach.

摘要

吉特林综合征是一种罕见的遗传性肾小管病,其特征为低钾血症、低镁血症和代谢性碱中毒。它是由基因中的突变引起的,导致远曲小管中噻嗪类敏感的氯化钠共转运体和镁转运体功能障碍。关于患有吉特林综合征的孕妇的报道很少。由于关于其对妊娠以及母婴结局的影响存在许多未解决的问题,产科和麻醉管理仍然是一项挑战。我们讨论了一名22岁新诊断为吉特林综合征的女性行剖宫产术的病例,重点关注麻醉方法。

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