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去骨瓣减压术治疗急性大脑中动脉梗死患者的效果。

Effect of decompressive hemicraniectomy in patients with acute middle cerebral artery infarction.

机构信息

Department of Neurosurgery, School of Medicine, Başkent University, Adana, Turkey

Department of Neurology, School of Medicine, Başkent University, Adana, Turkey

出版信息

Turk J Med Sci. 2021 Aug 30;51(4):2057-2065. doi: 10.3906/sag-2011-66.

Abstract

BACKGROUND/AIM: We aimed to determine in which cases this procedure may be more effective based on the data of patients who underwent decompressive hemicraniectomy (DHC).

MATERIAL AND METHODS

Overall, 47 patients who underwent DHC due to acute middle cerebral artery (MCA) infarction between January 2014 and january 2019 were retrospectively investigated. These patients were divided into two groups: those who died after DHC (Group A) and those who survived DHC (Group B). The groups were compared in terms of various parameters. We investigated whether the patient’s modified Rankin scale (mRS) status changed depending on age (> 60 and < 60 years).

RESULTS

The median age of all patients was 65 (37–80) years; groups A and B had median ages of 66.5 (37–80) and 61 (44–79) years (p = 0.111), respectively; 55.3% patients were male. The elapsed times until hospitalization after the onset of symptoms were 4.5 and 3 h in groups A and B, respectively (p = 0.014). The median GCS score at the time of admission was 7 (5–12) and 10 (8–14) in groups A and B, respectively (p = 0.0001). At the time of admission, 63.3% patients in group A had anisocoria, whereas no patient in group B had anisocoria (p = 0.0001). In postoperative period, 40% patients in group A and all patients in group B received AC/AA treatment. The survival of patients aged < 60 and > 60 years who underwent DHC for MCA infraction was 61.5% and 26.5%, respectively (p = 0,041). The median mRS of patients < 60 and > 60 years were 4 (1–6) and 6 (1–6), respectively (p = 0.018).

CONCLUSION

Age, DHC timing, and elapsed time until hospitalization or access to treatment directly affect the functional outcome and survival in MCA-infarcted patients who underwent DHC. In patients in whom the medical treatment fails, early DHC administration will increase survival without waiting for neurological worsening once herniation is detected radiologically.

摘要

背景/目的:我们旨在根据接受减压性半脑切除术(DHC)的患者的数据,确定在哪些情况下该手术更为有效。

材料和方法

回顾性分析了 2014 年 1 月至 2019 年 1 月期间因急性大脑中动脉(MCA)梗死而接受 DHC 的 47 例患者。这些患者分为两组:DHC 后死亡的患者(A 组)和 DHC 后存活的患者(B 组)。比较两组的各项参数。我们调查了患者的改良 Rankin 量表(mRS)状况是否因年龄(> 60 岁和< 60 岁)而异。

结果

所有患者的中位年龄为 65(37-80)岁;A 组和 B 组的中位年龄分别为 66.5(37-80)岁和 61(44-79)岁(p = 0.111);55.3%的患者为男性。A 组和 B 组患者自发病至住院的时间分别为 4.5 小时和 3 小时(p = 0.014)。入院时,A 组和 B 组的中位 GCS 评分为 7(5-12)分和 10(8-14)分(p = 0.0001)。入院时,A 组 63.3%的患者存在瞳孔不等大,而 B 组无患者存在瞳孔不等大(p = 0.0001)。术后,A 组 40%的患者和 B 组所有患者均接受 AC/AA 治疗。MCA 梗死行 DHC 治疗的< 60 岁和> 60 岁患者的生存率分别为 61.5%和 26.5%(p = 0.041)。< 60 岁和> 60 岁患者的中位 mRS 分别为 4(1-6)分和 6(1-6)分(p = 0.018)。

结论

年龄、DHC 时机以及自发病至住院或接受治疗的时间均直接影响接受 DHC 的 MCA 梗死患者的功能结局和生存情况。对于药物治疗无效的患者,一旦影像学发现脑疝,即可进行早期 DHC 治疗,无需等待神经恶化,从而提高生存率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0ed/8569743/e4911ec8c956/turkjmedsci-51-2057-fig001.jpg

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