妊娠中期母体血液一氧化氮相关基因和 miRNA 表达与早产有关。
Mid-pregnancy maternal blood nitric oxide-related gene and miRNA expression are associated with preterm birth.
机构信息
Department of Obstetrics & Gynecology, Division of Maternal Fetal Medicine, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
Institute for Environmental Health Solutions, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Epigenomics. 2021 May;13(9):667-682. doi: 10.2217/epi-2020-0346. Epub 2021 Apr 23.
Abstract
The nitric oxide (NO) pathway modulates inflammation and may influence birth timing. Case-control analysis of 136 pregnant women with RNA obtained <28 weeks; n = 212 mRNAs and n = 108 miRNAs in the NO pathway were evaluated. NO-pathway mRNA and miRNA transcript counts in women delivering preterm versus at term were compared, miRNA-mRNA expression levels correlated and prediction models generated. Fourteen genes were differentially expressed in women delivering <37 weeks; 13/14 were also differentially expressed in those delivering <34 weeks (q <0.10) versus term births. Multiple miRNA-mRNA pairs were correlated. Models with gene expression better predicted prematurity than models with only clinical or nongenomic predictors. Maternal blood NO pathway-related mRNA and miRNA expression is associated with prematurity.
摘要
一氧化氮（NO）通路调节炎症反应，并可能影响分娩时间。对 136 名妊娠<28 周的孕妇进行病例对照分析；在 NO 通路中评估了 212 个信使 RNA（mRNA）和 108 个微小 RNA（miRNA）。比较了早产和足月分娩孕妇的 NO 通路 mRNA 和 miRNA 转录本计数，分析了 miRNA-mRNA 表达水平的相关性，并生成了预测模型。在<37 周分娩的孕妇中，有 14 个基因表达差异；在<34 周分娩的孕妇中，13/14 个基因也表达差异（q<0.10），与足月分娩相比。多个 miRNA-mRNA 对相关。基于基因表达的模型比仅基于临床或非基因组预测因素的模型更能预测早产。母体血液中与 NO 通路相关的 mRNA 和 miRNA 表达与早产有关。
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