State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, P. R. China.
Department of Chemistry, School of Science, University of Management and Technology, CII, Johar Town, Lahore, 54770, Pakistan.
Biomater Sci. 2021 May 18;9(10):3851-3859. doi: 10.1039/d1bm00164g.
A flexible antibacterial fibrous membrane employing high antibacterial efficiency has great potential in healthcare applications. Herein, a three-dimensional copper(ii) metal-organic framework [Cu2(CA)(H2O)2, Cu-MOF-1] and poly(lactic acid) (PLA) composite fibrous membrane was prepared through a facile electrospinning method. The sphere-like Cu-MOF-1 was rapidly synthesized by a microwave-assisted hydrothermal reaction of Cu(ii) salts with citric acid (H4CA) in the presence of polyvinyl pyrrolidone (PVP). The surface morphology, thermal stability, mechanical properties and hydrophilicity test of the as-prepared Cu-MOF-1/PLA fibrous membrane were studied systematically. Compared with commercial copper nanoparticles (Cu-NPs), citric acid and copper citrate, Cu-MOF-1 showed higher antibacterial properties with the bacteriostatic rates of 97.9% and 99.3% against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively, when the used dose was 250 μg mL-1. The Cu-MOF-1/PLA fibrous membrane also exhibited outstanding bactericidal activities against E. coli and S. aureus with the antibacterial rates up to 99.3% and 99.8%, respectively. Mechanism investigation indicated that the slowly released Cu2+ ions could destroy the microenvironment of bacteria cells and destroy the integrity and permeability of the cell membrane, leading to enzyme inactivation. Therefore, the as-prepared flexible fibrous membrane will advance progress toward developing a broad spectrum antibacterial textile for healthcare protection related applications.
一种具有高效抗菌性能的柔性抗菌纤维膜在医疗保健应用中具有巨大的潜力。本文通过简便的静电纺丝方法制备了一种三维铜（ii）金属-有机骨架[Cu2(CA)(H2O)2，Cu-MOF-1]和聚乳酸（PLA）复合纤维膜。通过微波辅助水热反应，在聚维酮（PVP）存在下，Cu（ii）盐与柠檬酸（H4CA）快速合成了球形 Cu-MOF-1。系统研究了所制备的 Cu-MOF-1/PLA 纤维膜的表面形貌、热稳定性、力学性能和亲水性测试。与商业铜纳米颗粒（Cu-NPs）、柠檬酸和柠檬酸铜相比，Cu-MOF-1 在 250μg mL-1 用量下对大肠杆菌（E. coli）和金黄色葡萄球菌（S. aureus）的抑菌率分别达到 97.9%和 99.3%，具有更高的抗菌性能。Cu-MOF-1/PLA 纤维膜对大肠杆菌和金黄色葡萄球菌也表现出出色的杀菌活性，抗菌率分别高达 99.3%和 99.8%。机制研究表明，缓慢释放的 Cu2+离子可以破坏细菌细胞的微环境，破坏细胞膜的完整性和通透性，导致酶失活。因此，所制备的柔性纤维膜将推动开发广谱抗菌纺织品，用于医疗保健相关应用。
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