Qian Yangwei, Wang Chenxi, Xu Ruru, Wang Jin, Chen Qinyue, Zhu Zirui, Hu Quan, Shen Qiying, Shen Jia-Wei
School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, People's Republic of China.
Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, People's Republic of China.
J Nanobiotechnology. 2025 Feb 22;23(1):135. doi: 10.1186/s12951-025-03220-5.
It is urgent to exploit multifunctional materials and combined approaches for efficient antitumor effects. Copper-based metal-organic frameworks (Cu-MOFs) have excellent performances in catalysis, biocompatibility, photothermal conversion, and regulate metabolism, which make them attract more and more attention in antitumor application. Therefore, in this review, representative ligands, synthetic methods, antitumor mechanism, and antitumor applications of Cu-MOFs were provided. Special emphasis is placed on the recent antitumor applications of Cu-MOFs in drug carriers, antitumor therapy, tumor imaging, and theranostic, which are summarized with examples. Finally, we presented the dilemma faced by Cu-MOFs and offered a new perspective for future antitumor application. Hopefully, this review may serve as a reference for further development and application of Cu-MOFs.
开发具有高效抗肿瘤作用的多功能材料和联合方法迫在眉睫。铜基金属有机框架（Cu-MOFs）在催化、生物相容性、光热转换和调节代谢方面具有优异性能，这使其在抗肿瘤应用中越来越受到关注。因此，本综述介绍了Cu-MOFs的代表性配体、合成方法、抗肿瘤机制及抗肿瘤应用。特别强调了Cu-MOFs在药物载体、抗肿瘤治疗、肿瘤成像和诊疗方面的最新抗肿瘤应用，并举例进行了总结。最后，我们阐述了Cu-MOFs面临的困境，并为其未来的抗肿瘤应用提供了新的视角。希望本综述能为Cu-MOFs的进一步开发和应用提供参考。
