用亲核氟拦截巴纳特级联反应：直接合成α-氟化的1,2,3-三唑。
Intercepting the Banert cascade with nucleophilic fluorine: direct access to α-fluorinated H-1,2,3-triazoles.
作者信息
Alexander J R, Kevorkian P V, Topczewski J J
机构信息
Department of Chemistry, University of Minnesota Twin Cities, Minneapolis, Minnesota 55455, USA.
出版信息
Chem Commun (Camb). 2021 May 20;57(41):5024-5027. doi: 10.1039/d1cc01179k.
Abstract
The treatment of propargylic azides with silver(i) fluoride in acetonitrile was found to yield α-fluorinated NH-1,2,3-triazoles via the Banert cascade. The reaction was regioselective and the products result from an initial [3,3] rearrangement. The reaction is demonstrated on >15 examples with yields ranging from 37% to 86%.
摘要
发现在乙腈中用氟化银（I）处理炔丙基叠氮化物可通过巴纳特串联反应生成α-氟化的NH-1,2,3-三唑。该反应具有区域选择性，产物由初始的[3,3]重排产生。该反应在15多个实例中得到证实，产率范围为37%至86%。
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