Enamine Ltd., Chervonotkatska 78, 02094 Kyiv, Ukraine.
Chemistry Department, Taras Shevchenko National University of Kyiv, Volodymyrska 64, 01601 Kyiv, Ukraine.
Chem Rev. 2021 Feb 10;121(3):1670-1715. doi: 10.1021/acs.chemrev.0c01015. Epub 2020 Dec 31.
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all contributions on the topic have been published in the last 5 years. In this review, analysis of novel synthetic approaches to fluorinated pyrazoles that appeared in recent years is performed. A particular emphasis is devoted to a detailed consideration of reaction mechanisms. In addition, the reasons that have led to the ever-increasing popularity of fluorinated pyrazoles in various areas of science are discussed. At the end of the review, several potentially interesting but yet mostly unknown classes of fluorinated pyrazoles are outlined.
氟代吡唑在药物化学、药物发现、农业化学、配位化学和有机金属化学中起着重要的作用。自 20 世纪 90 年代初以来，它们的应用呈指数级增长。此外，在过去 5 年中，超过 50%的相关研究都集中在该主题上。在这篇综述中，对近年来出现的新型氟代吡唑合成方法进行了分析。特别强调了对反应机制的详细考虑。此外，还讨论了导致氟代吡唑在科学的各个领域越来越受欢迎的原因。在综述的最后，概述了几种具有潜在应用前景但目前尚未被充分研究的氟代吡唑类别。
