Chair of Inorganic Functional Materials, Kiel University, Kiel, Germany.
Section Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel University, Kiel, Germany.
Expert Rev Med Devices. 2021 Jun;18(6):569-579. doi: 10.1080/17434440.2021.1920923. Epub 2021 Jul 10.
Braided flow diverters (FD) are highly sophisticated, delicate, and intricate mechanical devices used to treat intracranial aneurysms. Testing such devices in vitro, however, remains an unsolved challenge. Here, we evaluate methods to measure flow, design and mechanical properties in vitro.
Flow properties, cell porosity, pore density, and cell area were evaluated under geometrically realistic conditions by placing FDs in patient-derived, 3D-printed models of human vasculature. 4D flow MRI was used to measure fluid dynamics. Laser microscopy was used to measure the design properties of the FDs. New methods were developed to investigate the bending, circumferential, and longitudinal radial force of the FDs continuously over varying diameters.
The placement and flow properties of the FD in the vasculature models were successfully measured by MRI, although artifacts occurred. Likewise, the porosity, pore density, and cell area were successfully measured inside of the models using a laser microscope. The newly developed mechanical methods allowed to measure the indicated forces - to our knowledge for the first time - continuously.
Modern and specifically tailored techniques, some of which were presented here for the first time, allow detailed insights into the flow, design, and mechanical properties of braided flow diverter stents.
编织型血流导向装置（FD）是高度复杂、精细和复杂的机械装置，用于治疗颅内动脉瘤。然而，此类装置的体外测试仍然是一个尚未解决的挑战。在这里，我们评估了在体外测量流量、设计和机械性能的方法。
通过将 FD 放置在患者衍生的、人体血管的 3D 打印模型中，在几何上逼真的条件下评估流量特性、细胞孔隙率、孔密度和细胞面积。4D 流 MRI 用于测量流体动力学。激光显微镜用于测量 FD 的设计特性。开发了新的方法来连续测量 FD 的弯曲、周向和纵向径向力，变化直径。
通过 MRI 成功测量了 FD 在血管模型中的放置和流动特性，尽管出现了伪影。同样，使用激光显微镜成功地测量了模型内部的孔隙率、孔密度和细胞面积。新开发的机械方法允许连续测量所指示的力 - 据我们所知，这是第一次。
现代且专门定制的技术，其中一些是首次在这里提出，允许对编织型血流导向支架的流动、设计和机械性能进行详细的了解。
