Johnson H M, Torres B A
J Immunol. 1985 Aug;135(2 Suppl):773s-775s.
The neurohypophyseal hormones arginine vasopressin (AVP) and oxytocin are capable of replacing the interleukin 2 (IL 2) requirement for T cell mitogen induction of gamma-interferon (IFN-gamma) in mouse spleen cell cultures. The structural basis for the helper signal by these hormones resides in the six N-terminal amino acids of AVP based on the relative ability of AVP, oxytocin, vasotocin, and pressinoic acid (AVP six N-terminal amino acid peptide) to help in IFN-gamma induction. AVP and pressinoic acid provide maximal help at 10(-10) M, while oxytocin and vasotocin with isoleucine at position three in place of phenylalanine are 10-fold less effective. An AVP competitive antagonist of vasopressor activity blocks the AVP helper signal for production of IFN-gamma, while having no effect on IL 2 help. This suggests that the AVP helper signal operates via binding to an AVP vasopressor-type receptor on lymphocytes.
神经垂体激素精氨酸加压素（AVP）和催产素能够替代白细胞介素2（IL-2），满足小鼠脾细胞培养中T细胞丝裂原诱导γ干扰素（IFN-γ）的需求。基于AVP、催产素、加压素和加压素酸（AVP六个N端氨基酸肽）在IFN-γ诱导中的相对作用能力，这些激素辅助信号的结构基础存在于AVP的六个N端氨基酸中。AVP和加压素酸在10^(-10)M时提供最大辅助作用，而在第三位含有异亮氨酸而非苯丙氨酸的催产素和加压素的效力则低10倍。一种AVP血管升压活性的竞争性拮抗剂可阻断AVP对IFN-γ产生的辅助信号，而对IL-2的辅助作用无影响。这表明AVP辅助信号是通过与淋巴细胞上的AVP血管升压素型受体结合发挥作用的。
