Bracci R, Buonocore G, Talluri B, Berni S
Division of Neonatology, University of Siena, Italy.
Acta Paediatr Scand. 1988 May;77(3):349-56. doi: 10.1111/j.1651-2227.1988.tb10659.x.
Determinations of erythrocyte enzyme scavengers of oxygen radicals (glutathione-peroxidase, superoxide-dismutase and catalase) and determinations of erythrocyte age-dependent glycolytic activities (glucose-6-phosphate-dehydrogenase, pyruvate-kinase and glucose-phosphate-isomerase) were carried out in cord blood and in the blood taken on the 4th day of life in 152 newborn infants with different peak bilirubin levels. The enzyme activities scavenging oxygen radicals, glutathione-peroxidase and superoxide-dismutase were significantly lower in infants with peak bilirubinemia higher than 214 mumol/l, compared to less-jaundiced neonates, both at birth and on the 4th day of life; their values correlated negatively with peak bilirubinemia at birth and on the 4th day of life. Glycolytic age-dependent enzyme activities were significantly higher in more jaundiced newborn infants only on the 4th day of life, when their values correlated positively with peak bilirubinemia. The results of this investigation suggest that a deficiency of factors protecting from oxygen toxicity, may play a role in the development of neonatal hemolysis and jaundice.
对152名不同峰值胆红素水平的新生儿的脐血及出生后第4天采集的血液进行了红细胞氧自由基清除酶（谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶）的测定，以及红细胞年龄依赖性糖酵解活性（葡萄糖-6-磷酸脱氢酶、丙酮酸激酶和葡萄糖磷酸异构酶）的测定。与黄疸较轻的新生儿相比，峰值胆红素血症高于214μmol/l的婴儿在出生时和出生后第4天，清除氧自由基的酶活性，即谷胱甘肽过氧化物酶和超氧化物歧化酶显著降低；其值与出生时和出生后第4天的峰值胆红素血症呈负相关。仅在出生后第4天，黄疸较重的新生儿的年龄依赖性糖酵解酶活性显著更高，此时其值与峰值胆红素血症呈正相关。本研究结果表明，保护机体免受氧毒性的因素缺乏可能在新生儿溶血和黄疸的发生中起作用。
