Department of Immunology, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Department of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Transbound Emerg Dis. 2022 May;69(3):958-973. doi: 10.1111/tbed.14118. Epub 2021 May 15.
Bovine tuberculosis (bTB) is one of the major zoonotic concerns of the world, as milk and meat from cattle are major products for human consumption. Bovine tuberculosis not only affects the health of cattle and poses an imminent zoonotic threat, but also causes significant economic loss in both developed and developing countries. This systematic review reports the prevalence of Mycobacterium tuberculosis complex (MTBC) organisms in slaughtered cattle showing tuberculosis-like lesion (TBL) with available literature worldwide. Appropriate keywords were used to search various databases to collect articles pertaining to slaughterhouse studies. Bovine TB prevalence, based on the prevalence of MTBC organisms in slaughtered cattle showing TBL by culture, microscopy, PCR and spoligotyping, was assessed in each study using a random-effects model and standardized mean with 95% confidence interval (CI). Heterogeneity was assessed by the I statistic. Publication bias was evaluated using funnel plots. Out of 72 hits, 37 studies were selected based on title and abstract. Ten articles were excluded due to lack of desired data, and 27 studies were included in the final analysis. From the selected articles, it was found that 426 [95% CI: 302-560] per 1,000 slaughtered cattle with TBL were positive for the presence of MTBC organisms. The sensitivity analysis showed that no individual study alone influenced the estimation of pooled prevalence. The prevalence of MTBC organisms in slaughtered cattle showing TBL by culture, microscopy, PCR and spoligotyping was 474[95% CI: 342-610], 385 [95% CI: 269-515], 218 [95% CI: 132-338], 326 [95% CI: 229-442], respectively, per 1,000 slaughtered cattle. Most of the slaughtered cattle were from the same locality as the slaughterhouse. The results obtained in this study suggest that abattoir monitoring can give an estimate of the prevalence of bTB in that locality. This study also emphasizes the need to test cattle and animal handlers who were in contact with bTB-positive cattle.
牛结核病（bTB）是世界上主要的人畜共患病之一，因为牛的奶和肉是人类消费的主要产品。牛结核病不仅影响牛的健康，构成迫在眉睫的人畜共患病威胁，而且在发达国家和发展中国家都造成重大经济损失。本系统评价报告了世界范围内有结核病样病变（TBL）屠宰牛中结核分枝杆菌复合群（MTBC）生物体的流行情况。使用适当的关键词在各种数据库中搜索与屠宰场研究相关的文章。根据培养、显微镜检查、PCR 和 spoligotyping 检测显示 TBL 的屠宰牛中 MTBC 生物体的流行率，采用随机效应模型和标准化均值（95%置信区间 [CI]）评估每一项研究的牛结核病流行率。采用 I 统计量评估异质性。采用漏斗图评估发表偏倚。在 72 个命中中，根据标题和摘要选择了 37 项研究。由于缺乏所需数据，10 项研究被排除在外，最终有 27 项研究纳入最终分析。从入选的文章中发现，426 头（95%CI：302-560）每 1000 头 TBL 屠宰牛对 MTBC 生物体呈阳性。敏感性分析表明，没有单独的研究影响汇总流行率的估计。培养、显微镜检查、PCR 和 spoligotyping 检测显示 TBL 的屠宰牛中 MTBC 生物体的流行率分别为 474（95%CI：342-610）、385（95%CI：269-515）、218（95%CI：132-338）、326（95%CI：229-442）。屠宰牛大多来自与屠宰场相同的地区。本研究结果表明，屠宰场监测可以估计当地牛结核病的流行率。本研究还强调需要对接触 bTB 阳性牛的牛和动物饲养员进行检测。
