Kusuyama Y, Yoshida M, Uekado Y, Ogawa T, Fujinaga T, Kuribayashi K, Saito K
Division of Pathology, Wakayama Rosai Hospital, Japan.
Acta Pathol Jpn. 1988 Feb;38(2):217-23. doi: 10.1111/j.1440-1827.1988.tb01099.x.
A case of urethral clear cell adenocarcinoma (mesonephric carcinoma) in a 62-year-old woman is reported. The patient consulted our hospital because of acute urinary retention. Fine needle aspiration cytology showed a few atypical cells; loose cluster cells with finely vacuolated cytoplasm, large nuclei and prominent nucleoli, and small cluster cells with finely vacuolated, delicate cytoplasm, small pale nuclei and small nucleoli. Cytologic diagnosis was adenocarcinoma and no diagnosis of clear cell adenocarcinoma was obtained. The neoplasia was localized at the posterior wall of the urethra and deep muscular layer of the vaginal wall. Histologically, the tumor revealed mainly small, elongated glands consisting of single-layered cuboidal or columnar cells with scanty cytoplasm and a focally hobnail appearance. In addition, a small cystic lesion resembling nephrogenic adenoma was observed. This finding raises the possibility that clear cell adenocarcinoma may be a malignant counterpart of nephrogenic adenoma.
报告了一例62岁女性尿道透明细胞腺癌（中肾腺癌）的病例。患者因急性尿潴留前来我院就诊。细针穿刺细胞学检查显示少量非典型细胞；疏松聚集的细胞，胞质有细小空泡，细胞核大，核仁明显，以及小簇状细胞，胞质有细小空泡、细腻，细胞核小而淡染，核仁小。细胞学诊断为腺癌，未得出透明细胞腺癌的诊断。肿瘤位于尿道后壁和阴道壁深层肌肉层。组织学上，肿瘤主要表现为小的、细长的腺体，由单层立方或柱状细胞组成，胞质稀少，局部呈鞋钉样外观。此外，还观察到一个类似肾源性腺瘤的小囊性病变。这一发现增加了透明细胞腺癌可能是肾源性腺瘤恶性对应物的可能性。
