Kuroda N, Shiotsu T, Ohara M, Hirouchi T, Mizuno K, Miyazaki E
Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Kochi, Japan.
APMIS. 2006 Apr;114(4):314-8. doi: 10.1111/j.1600-0463.2006.apm_345.x.
We here report a very rare case of female urethral adenocarcinoma. A 77-year-old woman presented with urinary retention. Cystoscopy showed a urethral tumor and the biopsy material showed adenocarcinoma. Macroscopically, the tumor measuring 3.0 x 3.0 x 2.4 cm was predominantly observed around the periurethral area on the proximal side. Histologically, patterns of columnar/mucinous adenocarcinoma, clear cell adenocarcinoma and papillary/micropapillary carcinoma were observed, but there was no evidence of a cribriform pattern. Immunohistochemically, neoplastic cells of at least one of three components were positive for CK7 and CK20 or CA125. We suggest that female urethral adenocarcinoma with a histologically and immunohistochemically heterogeneous phenotype may originate from cells within urethral or paraurethral tissue, such as urethritis glandularis or intestinal metaplastic epithelium and Mullerian tissue.
我们在此报告一例极为罕见的女性尿道腺癌病例。一名77岁女性因尿潴留就诊。膀胱镜检查发现尿道肿瘤，活检材料显示为腺癌。大体上，肿瘤大小为3.0×3.0×2.4 cm，主要见于近端尿道周围区域。组织学上，观察到柱状/黏液腺癌、透明细胞腺癌和乳头状/微乳头状癌的形态，但未见筛状结构。免疫组化显示，三种成分中至少一种的肿瘤细胞CK7、CK20或CA125呈阳性。我们认为，具有组织学和免疫组化异质性表型的女性尿道腺癌可能起源于尿道或尿道旁组织中的细胞，如腺性尿道炎或肠化生上皮以及苗勒氏组织。
