Department of Anatomy, Cell Biology & Physiology, Indiana University School of Medicine, Indianapolis, IN, United States of America.
Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN, United States of America.
PLoS One. 2021 Apr 23;16(4):e0250438. doi: 10.1371/journal.pone.0250438. eCollection 2021.
Chronic kidney disease (CKD) causes bone loss, particularly in cortical bone, through formation of cortical pores which lead to skeletal fragility. Animal models of CKD have shown variability in the skeletal response to CKD between males and females suggesting sex may play a role in this variation. Our aim was to compare the impact of adenine-induced CKD on cortical parameters in skeletally mature male and female C57Bl/6 mice. After 10-weeks of adenine-induced CKD, both male and female adenine mice had high serum parathyroid hormone (PTH), high bone turnover, and cortical porosity compared to non-CKD controls. Both sexes had lower cortical thickness, but only male mice had lower cortical bone area. CKD imparted greater deficits in mechanical properties of male mice compared to female mice. These data demonstrate that both male and female mice develop high PTH/high bone turnover in response to adenine-induced CKD and that cortical bone phenotypes are slightly more severe in males, particularly in mechanical properties deficits.
慢性肾脏病（CKD）会导致骨丢失，尤其是皮质骨丢失，形成皮质孔，导致骨骼脆弱。CKD 的动物模型表明，男性和女性对 CKD 的骨骼反应存在差异，这表明性别可能在这种变化中起作用。我们的目的是比较腺嘌呤诱导的 CKD 对骨骼成熟的雄性和雌性 C57Bl/6 小鼠皮质参数的影响。经过 10 周的腺嘌呤诱导的 CKD，与非 CKD 对照组相比，雄性和雌性腺嘌呤小鼠的血清甲状旁腺激素（PTH）水平均升高，骨转换率高，皮质多孔。两种性别的皮质厚度均降低，但只有雄性小鼠的皮质骨面积降低。与雌性小鼠相比，CKD 使雄性小鼠的机械性能缺陷更大。这些数据表明，雄性和雌性小鼠均对腺嘌呤诱导的 CKD 产生高 PTH/高骨转换反应，并且皮质骨表型在男性中略更严重，尤其是在机械性能缺陷方面。
