Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Phytother Res. 2021 Sep;35(9):4782-4794. doi: 10.1002/ptr.7110. Epub 2021 Apr 23.
A growing literature indicates several health benefits of theanine, a major nonprotein derivative amino acid special to tea, and a nonedible mushroom. This study aimed to systematically review the scientific evidence regarding the anticarcinogen and anticancer effects of natural theanine. A systematic search for the relevant articles published until January 2021 on MEDLINE, Scopus, and Web of Knowledge was conducted. Out of 377 initial records, 14 in vitro, ex vivo, and in vivo studies met our inclusion criteria. Most of the included in vitro and ex vivo studies reported beneficial effects of theanine on the proliferation, apoptosis, metastasis, migration, and invasion in various cancer cell lines. The in vivo studies also supported the potential impacts of theanine on cancer incidence or progression. Theanine exerted its anticancer function by inhibiting EGFR, VEGFR, Met, and Akt/mTOR, JAK2/STAT3, and ERK/NFκB pathways, as well as activating the intrinsic apoptosis pathway and caspase-independent programmed cell death. In conclusion, the results indicated moderate apoptotic, antimetastatic, antimigration, and anti-invasion effects, along with the mild antiproliferative influence of theanine on cancer. Further studies are necessary to ascertain the effectiveness of theanine on the prevention and suppression of cancer and shed light upon the attributable mechanisms in the in vivo condition.
越来越多的文献表明，茶和非食用蘑菇特有的一种主要非蛋白质衍生氨基酸——茶氨酸具有多种健康益处。本研究旨在系统综述关于天然茶氨酸的抗癌和防癌作用的科学证据。系统检索了截至 2021 年 1 月 MEDLINE、Scopus 和 Web of Knowledge 上发表的相关文章。在 377 条初始记录中，有 14 项符合我们的纳入标准，包括体外、离体和体内研究。大多数纳入的体外和离体研究报告了茶氨酸对各种癌细胞系增殖、凋亡、转移、迁移和侵袭的有益影响。体内研究也支持茶氨酸对癌症发病率或进展的潜在影响。茶氨酸通过抑制 EGFR、VEGFR、Met 和 Akt/mTOR、JAK2/STAT3 和 ERK/NFκB 通路，以及激活内在凋亡途径和 caspase 非依赖性程序性细胞死亡，发挥其抗癌功能。总之，结果表明茶氨酸对癌症具有中度的促凋亡、抗转移、抗迁移和抗侵袭作用，以及轻度的抗增殖作用。需要进一步的研究来确定茶氨酸在癌症预防和抑制中的有效性，并阐明体内条件下的归因机制。
