从一名携带 LDLR c.T1241G 和 APOB c.G1618T 变异的家族性高胆固醇血症患者中生成人诱导多能干细胞系 CIBi009-A。
Generation of a human iPSC line CIBi009-A from a patient with familial hypercholesterolemia carrying variants of LDLR c.T1241G and APOB c.G1618T.
机构信息
Department of Cardiology, The First People's Hospital of Shangqiu, Shangqiu 476100, China.
Department of Histology and Embryology, College of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
出版信息
Stem Cell Res. 2021 May;53:102347. doi: 10.1016/j.scr.2021.102347. Epub 2021 Apr 20.
PMID:33892292
Abstract
Patients with familial hypercholesterolemia (FH) are susceptible to premature coronary artery disease. We generated a human iPSC line CIBi009-A from a patient with FH who carried variants of LDLR c.T1241G and APOB c.G1618T. This line will be a valuable resource for investigating novel therapeutic approaches to FH.
摘要
家族性高胆固醇血症（FH）患者易患早发冠心病。我们从一位携带 LDLR c.T1241G 和 APOB c.G1618T 变异的 FH 患者中生成了一个人诱导多能干细胞系 CIBi009-A。该细胞系将成为研究 FH 新型治疗方法的宝贵资源。
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