Trac Judy, Keck J Myles, Deweese Joseph E
Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, One University Park Drive, Nashville, TN, 37204-3951, USA.
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232-0146, USA.
J Cannabis Res. 2021 Apr 23;3(1):11. doi: 10.1186/s42238-021-00067-z.
Cannabidiol and related cannabinoids are under exploration for the treatment of a number of disease states. The cannabinoid-quinone HU-331 has been studied as a potential anticancer therapeutic. Previous studies provide evidence that HU-331 displays anticancer activity without some of the known adverse events associated with traditional anticancer agents. In this brief review, we will explore the literature related to the activity of HU-331 in purified systems, cancer cell lines, and animal models. For example, HU-331 displays inhibitory activity against human topoisomerase IIα, a known anticancer drug target. Further, in multiple cell model systems, the IC value for HU-331 was less than 10 μM. In addition, mouse model systems demonstrate the ability of HU-331 to shrink tumors without causing cardiotoxicity. In addition, we will briefly review the activity of some key analogs and derivatives of HU-331 for various disease states. Taken together, the published studies support further exploration of HU-331 for the treatment of cancer and possibly other disease states.
大麻二酚及相关大麻素正在被研究用于治疗多种疾病状态。大麻素-醌HU-331已作为一种潜在的抗癌治疗药物进行了研究。先前的研究表明，HU-331具有抗癌活性，且没有一些与传统抗癌药物相关的已知不良事件。在这篇简短的综述中，我们将探讨与HU-331在纯化系统、癌细胞系和动物模型中的活性相关的文献。例如，HU-331对人拓扑异构酶IIα显示出抑制活性，拓扑异构酶IIα是一种已知的抗癌药物靶点。此外，在多个细胞模型系统中，HU-331的IC值小于10μM。此外，小鼠模型系统证明了HU-331能够使肿瘤缩小而不引起心脏毒性。此外，我们还将简要综述HU-331的一些关键类似物和衍生物对各种疾病状态的活性。综上所述，已发表的研究支持进一步探索HU-331用于治疗癌症以及可能的其他疾病状态。
