Al-Eitan Laith Naser, Alahmad Saif Zuhair, Khair Iliya Yacoub
Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110, Jordan.
Curr Neuropharmacol. 2025;23(5):511-523. doi: 10.2174/1570159X23666240905125037.
Angiogenesis, the formation of new vasculature from preexisting vasculature, is involved in the development of several diseases as well as various physiological processes. Strict cooperation of proangiogenic and antiangiogenic factors mediates the control of angiogenesis. The fundamental steps in angiogenesis include endothelial cell proliferation, migration, and invasion. Addictive substances, which are considered therapeutic candidates in research and medicine, are classified as natural substances, such as nicotine, or synthetic substances, such as synthetic cannabinoids. Addictive substances have been shown to either enhance or suppress angiogenesis. This review article provides an overview of recent studies concerning the effects of several addictive substances on the process of angiogenesis. Google Scholar and PubMed were used to collect the scientific literature used in this review. The addictive substances addressed in this review are nicotine, opioids such as morphine and heroin, alcohol, cocaine, methamphetamine, and cannabinoids. An accurate assessment of the influence of these substances on the angiogenic process may help to construct a potentially effective therapeutic protocol to control and treat several angiogenesis-related diseases.
血管生成是指从已有的脉管系统形成新的脉管系统，它参与多种疾病的发展以及各种生理过程。促血管生成因子和抗血管生成因子之间的严格协作介导了对血管生成的控制。血管生成的基本步骤包括内皮细胞增殖、迁移和侵袭。成瘾性物质在研究和医学中被视为治疗候选物，可分为天然物质（如尼古丁）或合成物质（如合成大麻素）。已表明成瘾性物质可增强或抑制血管生成。这篇综述文章概述了近期关于几种成瘾性物质对血管生成过程影响的研究。使用谷歌学术和PubMed收集本综述中使用的科学文献。本综述中涉及的成瘾性物质有尼古丁、吗啡和海洛因等阿片类药物、酒精、可卡因、甲基苯丙胺和大麻素。准确评估这些物质对血管生成过程的影响可能有助于构建一个潜在有效的治疗方案，以控制和治疗几种与血管生成相关的疾病。
