Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
Cancer Genomics Proteomics. 2021 May-Jun;18(3):245-251. doi: 10.21873/cgp.20255. Epub 2021 Apr 23.
BACKGROUND/AIM: Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate the contribution of Matrix metalloproteinase-1 genotypes to CRC risk in Taiwan.
A total of 362 cases and 362 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined. The environmental factors and clinical-pathological records were also analyzed.
The genotypic frequency of MMP-1 rs1799750 were different between the CRC and control groups (p for trend=0.0083). 1G/2G and 1G/1G were associated with lower risk (p=0.0438 and 0.0030, adjusted OR=0.73 and 0.54, 95%CI=0.54-0.90 and 0.37-0.83). Among non-smokers, those with 1G/2G and 1G/1G genotypes were at 0.70- and 0.48-fold odds of having CRC. Among non-alcohol drinkers, people with 1G/2G and 1G/1G genotypes were at 0.71- and 0.54-fold odds. The 1G/1G genotype were statistically lower among CRC patients with lymph node metastasis (7.2%) than those without (19.0%).
The genotypes at MMP-1 rs1799705 play a role in determining susceptibility to CRC risk in Taiwan.
背景/目的：基质金属蛋白酶-1 负责细胞外基质的调节，其在结直肠癌（CRC）中的遗传作用尚不清楚。本研究旨在探讨基质金属蛋白酶-1 基因型对台湾 CRC 风险的贡献。
共纳入 362 例病例和 362 例对照，并检测其 MMP-1-1607（rs1799705）基因型。还分析了环境因素和临床病理记录。
CRC 组和对照组 MMP-1 rs1799750 的基因型频率不同（p 趋势=0.0083）。1G/2G 和 1G/1G 基因型与较低的风险相关（p=0.0438 和 0.0030，调整 OR=0.73 和 0.54，95%CI=0.54-0.90 和 0.37-0.83）。在不吸烟者中，1G/2G 和 1G/1G 基因型的 CRC 发病风险分别降低 0.70 倍和 0.48 倍。在不饮酒者中，1G/2G 和 1G/1G 基因型的 CRC 发病风险分别降低 0.71 倍和 0.54 倍。1G/1G 基因型在有淋巴结转移的 CRC 患者中（7.2%）明显低于无淋巴结转移的患者（19.0%）。
MMP-1 rs1799705 基因型在确定台湾 CRC 风险易感性方面发挥作用。
