台湾地区基因型对结直肠癌的影响。
Contribution of Genotypes to Colorectal Cancer in Taiwan.
机构信息
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.
Division of Colon and Rectal Surgery, Taichung Armed Forces General Hospital, Taichung, Taiwan, R.O.C.
出版信息
Cancer Genomics Proteomics. 2021 May-Jun;18(3):245-251. doi: 10.21873/cgp.20255. Epub 2021 Apr 23.
BACKGROUND/AIM: Matrix metalloproteinase-1 is responsible for extracellular matrix regulation, and its genetic role in colorectal cancer (CRC) is unclear. The aim of the study was to investigate the contribution of Matrix metalloproteinase-1 genotypes to CRC risk in Taiwan.
MATERIALS AND METHODS
A total of 362 cases and 362 controls were included and their MMP-1 -1607 (rs1799705) genotypes were examined. The environmental factors and clinical-pathological records were also analyzed.
RESULTS
The genotypic frequency of MMP-1 rs1799750 were different between the CRC and control groups (p for trend=0.0083). 1G/2G and 1G/1G were associated with lower risk (p=0.0438 and 0.0030, adjusted OR=0.73 and 0.54, 95%CI=0.54-0.90 and 0.37-0.83). Among non-smokers, those with 1G/2G and 1G/1G genotypes were at 0.70- and 0.48-fold odds of having CRC. Among non-alcohol drinkers, people with 1G/2G and 1G/1G genotypes were at 0.71- and 0.54-fold odds. The 1G/1G genotype were statistically lower among CRC patients with lymph node metastasis (7.2%) than those without (19.0%).
CONCLUSION
The genotypes at MMP-1 rs1799705 play a role in determining susceptibility to CRC risk in Taiwan.
背景/目的：基质金属蛋白酶-1 负责细胞外基质的调节，其在结直肠癌（CRC）中的遗传作用尚不清楚。本研究旨在探讨基质金属蛋白酶-1 基因型对台湾 CRC 风险的贡献。
材料和方法
共纳入 362 例病例和 362 例对照，并检测其 MMP-1-1607（rs1799705）基因型。还分析了环境因素和临床病理记录。
结果
CRC 组和对照组 MMP-1 rs1799750 的基因型频率不同（p 趋势=0.0083）。1G/2G 和 1G/1G 基因型与较低的风险相关（p=0.0438 和 0.0030，调整 OR=0.73 和 0.54，95%CI=0.54-0.90 和 0.37-0.83）。在不吸烟者中，1G/2G 和 1G/1G 基因型的 CRC 发病风险分别降低 0.70 倍和 0.48 倍。在不饮酒者中，1G/2G 和 1G/1G 基因型的 CRC 发病风险分别降低 0.71 倍和 0.54 倍。1G/1G 基因型在有淋巴结转移的 CRC 患者中（7.2%）明显低于无淋巴结转移的患者（19.0%）。
结论
MMP-1 rs1799705 基因型在确定台湾 CRC 风险易感性方面发挥作用。
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