Department of Ophthalmology, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine, Institute of Health Sciences, Jinju, South Korea.
Department of Laboratory Medicine, Gyeongsang National University Hospital and Gyeongsang National University College of Medicine, Jinju, South Korea.
Sci Rep. 2021 Apr 23;11(1):8814. doi: 10.1038/s41598-021-87931-3.
Aim of the study is to report the clinical characteristics and prognostic factors in hypertensive anterior uveitis (AU) diagnosed with multiplex polymerase chain reaction (PCR). Eighty-eight eyes of 88 patients with hypertensive AU were enrolled from 2015 to 2019 in a tertiary center in South Korea. All patients underwent multiplex PCR that was performed using aqueous humor samples collected at first visit to detect the DNA of six herpesviruses. Twenty-eight (31.8%) eyes were PCR positive. Herpes simplex virus was found in 6 (6.8%) eyes, varicella-zoster virus in 7 (8.0%) eyes, cytomegalovirus in 14 (15.9%) eyes, and Epstein-Barr virus in 1 (1.1%) eye. On multivariate regression analysis, PCR positivity was significantly associated with coin-shaped keratic precipitates (odds ratio (OR) = 6.01, P = 0.044). Recurrence and final visual acuity were significantly associated with a presumed diagnosis of viral endotheliitis (OR = 21.69, P = 0.04 and OR = 6.3, P = 0.004, respectively). This study showed the importance of PCR positivity, suggesting that identification of the virus through active PCR testing could affect the course, treatment, and prognosis of hypertensive AU.
报告用多重聚合酶链反应（PCR）诊断的高血压前葡萄膜炎（AU）的临床特征和预后因素。
本研究纳入了 2015 年至 2019 年在韩国一家三级中心诊断为高血压 AU 的 88 例 88 只眼患者的临床资料。所有患者均接受了多重 PCR 检测，使用首次就诊时采集的房水样本检测六种疱疹病毒的 DNA。
28 只（31.8%）眼 PCR 阳性。6 只（6.8%）眼单纯疱疹病毒阳性，7 只（8.0%）眼水痘-带状疱疹病毒阳性，14 只（15.9%）眼巨细胞病毒阳性，1 只（1.1%）眼 EBV 阳性。多因素回归分析显示，PCR 阳性与钱币状角膜后沉着物显著相关（比值比（OR）=6.01，P=0.044）。复发和最终视力与病毒性内皮炎的假定诊断显著相关（OR=21.69，P=0.04 和 OR=6.3，P=0.004）。
本研究表明 PCR 阳性的重要性，提示通过主动 PCR 检测识别病毒可能会影响高血压 AU 的病程、治疗和预后。
