Lang W, Borrusch H, Bauer L
Department of Pathology, Medical School, Hannover, Federal Republic of Germany.
Am J Clin Pathol. 1988 Jul;90(1):72-6. doi: 10.1093/ajcp/90.1.72.
In a sequence of 1,020 autopsies, all thyroid glands were thoroughly examined during a two-year period. Fifty-seven percent of the thyroid glands had no gross or histologic changes; approximately 22% were more or less goitrous. In 63 of 1,020 (6.2%) thyroid glands, a clinically latent carcinoma was detected. The greatest diameter of tumors measured microscopically ranged between 0.5 and 10.5 mm. Sixty-nine percent of the carcinomas were found by excision of a local change of tissue visible through close examination by the naked eye. All but one carcinoma were of papillary type, the one exception being a C-cell carcinoma. Multicentricity was found in 46% and regional lymph node metastases in 14%. There was no significant predilection of sex or age. It was concluded that these tumors have no propensity to increase to a clinically apparent thyroid disease.
在为期两年的1020例尸检中，对所有甲状腺进行了全面检查。57%的甲状腺无大体或组织学改变；约22%或多或少有甲状腺肿。在1020例甲状腺中，有63例（6.2%）检测到临床隐匿性癌。显微镜下测量的肿瘤最大直径在0.5至10.5毫米之间。69%的癌是通过切除肉眼仔细检查可见的局部组织变化发现的。除1例外，所有癌均为乳头状癌，唯一的例外是C细胞癌。46%发现有多中心性，14%有区域淋巴结转移。无明显的性别或年龄倾向。得出的结论是，这些肿瘤没有发展为临床明显甲状腺疾病的倾向。
