Department of Medical Biotechnology and Nanotechnology, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Biofactors. 2021 Jul;47(4):570-586. doi: 10.1002/biof.1735. Epub 2021 Apr 24.
Amyloidosis is a concept that implicates disorders and complications that are due to abnormal protein accumulation in different cells and tissues. Protein aggregation-associated diseases are classified according to the type of aggregates and deposition sites, such as neurodegenerative disorders and type 2 diabetes mellitus. Polyphenolic phytochemicals such as curcumin and its derivatives have anti-amyloid effects both in vitro and in animal models; however, the underlying mechanisms are not understood. In this review, we summarized possible mechanisms by which curcumin could interfere with self-assembly processes and reduce amyloid aggregation in amyloidosis. Furthermore, we discuss clinical trials in which curcumin is used as a therapeutic agent for the treatment of diseases linking to protein aggregates.
淀粉样变性是一个涉及多种疾病和并发症的概念，这些疾病和并发症是由于不同细胞和组织中异常蛋白质的积累引起的。蛋白质聚集相关疾病根据聚集物的类型和沉积部位进行分类，如神经退行性疾病和 2 型糖尿病。多酚类植物化学物质，如姜黄素及其衍生物，在体外和动物模型中均具有抗淀粉样变性作用；然而，其潜在机制尚不清楚。在这篇综述中，我们总结了姜黄素可能通过哪些机制干扰自组装过程并减少淀粉样变性中的淀粉样蛋白聚集。此外，我们还讨论了姜黄素作为治疗与蛋白质聚集相关疾病的治疗剂的临床试验。
