Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Division of Otolaryngology and Head and Neck Surgery, IEO European Institute of Oncology IRCCS, Milan, Italy.
Oral Dis. 2023 Jan;29(1):128-137. doi: 10.1111/odi.13885. Epub 2021 May 6.
The space comprised between tumor and neck lymph nodes (T-N tract) is one of the main routes of tumor spread in oral cavity tumors. Aim of the study was to investigate the impact of T-N tract involvement on the postoperative radiotherapy (PORT) outcomes.
Patients (pts) treated between 2000 and 2016 with indication to PORT were retrospectively retrieved. Inclusion criteria were: (a) locally advanced tumors of the oral cavity, (b) who received with indication to PORT (c) with a minimum follow-up of six months.
One hundred and fifty-seven pts met the inclusion criteria (136 pts treated with PORT and 21 pts not treated with PORT). In the PORT cohort, the T-N tract involvement had no impact on both OS (p = .09) and LRFS (p = .2). Among the non-PORT cohort, both OS (p = .007) and LRFS (p = .017) were worse for pts with positive T-N tract compared to those with negative T-N tract. PORT improved both OS (p = .008) and LRFS (p = .003) in pts with positive T-N tract but not in those with negative T-N tract (p = .36 and p = .37, respectively).
Our results suggest that involvement of T-N tract should be considered as prognostic factors informing the indication to PORT.
肿瘤和颈部淋巴结（T-N 道）之间的空间是口腔肿瘤肿瘤扩散的主要途径之一。本研究旨在探讨 T-N 道受累对术后放疗（PORT）结果的影响。
回顾性检索了 2000 年至 2016 年间接受 PORT 治疗的患者。纳入标准为：（a）口腔局部晚期肿瘤；（b）接受 PORT 治疗（c）随访至少 6 个月。
157 例患者符合纳入标准（PORT 组 136 例，未接受 PORT 组 21 例）。在 PORT 组中，T-N 道受累对 OS（p=0.09）和 LRFS（p=0.2）均无影响。在非 PORT 组中，与 T-N 道阴性的患者相比，T-N 道阳性的患者 OS（p=0.007）和 LRFS（p=0.017）均较差。PORT 改善了 T-N 道阳性患者的 OS（p=0.008）和 LRFS（p=0.003），但对 T-N 道阴性患者无影响（p=0.36 和 p=0.37）。
我们的结果表明，T-N 道受累应被视为预测 PORT 适应证的预后因素。
