Department of Chemical Engineering, Queen's University, Kingston, K7L 3N6, Canada.
Macromol Biosci. 2021 Jul;21(7):e2100085. doi: 10.1002/mabi.202100085. Epub 2021 Apr 24.
Aliphatic polycarbonates (APCs) have been studied for decades but have not been as utilized as aliphatic polyesters in biomaterial applications such as drug delivery and tissue engineering. With the recognition that functionalized aliphatic polymers can be readily synthesized, increased attention is being paid to these materials. A frequently provided reason for utilizing these polymers is that they degrade to form diols and carbon dioxide. However, depending on the structure and molecular weight of the APC, degradation may not occur. In this review, the mechanisms by which APCs and functionalized APCs have been found to degrade in vivo are examined with the objective of providing guidance in the continued development of these polymers as biomaterials.
脂肪族聚碳酸酯（APCs）已经研究了几十年，但在药物输送和组织工程等生物材料应用中，它们的应用不如脂肪族聚酯广泛。随着人们认识到可以方便地合成功能化的脂肪族聚合物，人们对这些材料的关注度越来越高。人们经常使用这些聚合物的一个原因是它们会降解形成二醇和二氧化碳。然而，根据 APC 的结构和分子量，降解可能不会发生。在本综述中，我们研究了体内发现的 APC 和功能化 APC 降解的机制，旨在为这些聚合物作为生物材料的进一步开发提供指导。
