Fukushima K
Department of Polymer Science and Engineering, Graduate School of Science and Engineering, Yamagata University, Yonezawa, Yamagata 992-8510, Japan.
Biomater Sci. 2016 Jan;4(1):9-24. doi: 10.1039/c5bm00123d.
Aliphatic polycarbonates have drawn attention as biodegradable polymers that can be applied to a broad range of resorbable medical devices. In particular, poly(trimethylene carbonate) (PTMC), its copolymers, and its derivatives are currently studied due to their unique degradation characteristics that are different from those of aliphatic polyesters. Furthermore, their flexible and hydrophobic nature has driven the application of PTMC-based polymers to soft tissue regeneration and drug delivery. This review presents the diverse applications and functionalization strategies of PTMC-based materials in relation to recent advances in medical technologies and their subsequent needs in clinical settings.
脂肪族聚碳酸酯作为可生物降解的聚合物已引起关注，可应用于广泛的可吸收医疗设备。特别是聚三亚甲基碳酸酯（PTMC）、其共聚物及其衍生物，由于其与脂肪族聚酯不同的独特降解特性，目前正在进行研究。此外，它们的柔韧性和疏水性推动了基于PTMC的聚合物在软组织再生和药物递送中的应用。本综述介绍了基于PTMC的材料在医疗技术最新进展及其在临床环境中的后续需求方面的各种应用和功能化策略。
