通过二十年回顾评估土耳其的丙型肝炎认知情况。

Retrospective Evaluation of Hepatitis C Awareness in Turkey Through Two Decades.

机构信息

Internal Medicine Department, Gastroenterology, Hacettepe University, Medical Faculty.

Biostatistics Department, Hacettepe University, Medical Faculty.

出版信息

Turk J Gastroenterol. 2021 Jan;32(1):88-96. doi: 10.5152/tjg.2020.19949.

DOI:10.5152/tjg.2020.19949

PMID:33893771

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8975459/

Abstract

BACKGROUND/AIMS: Chronic hepatitis C (CHC) is the only viral infection that can be treated with oral antiviral agents. However, CHC awareness is a major barrier to the World Health Organization's target of eliminating hepatitis C virus (HCV) by 2030. Here, CHC awareness trends were analyzed in Hacettepe University Hospital, Turkey, between January 2000 and December 2017.

MATERIALS AND METHODS

Central laboratory data were retrospectively analyzed for HCV test results (anti-HCV, HCV RNA, HCV genotype). After combining 548,141 anti-HCV test results, 395,103 cases were analyzed. The following two parameters were defined for CHC awareness: (1) the presence of HCV RNA results for anti-HCV positives and (2) the presence of a genotype result for HCV RNA positives.

RESULTS

Anti-HCV positives were older than negatives (mean age-years ± SD, 59.4 ± 19.0 vs. 44.0 ± 18.9), and the positivity rate was higher in women than in men (1.4% vs. 1.0%). Anti-HCV positivity decreased from 3.1% to 0.6% from 2000 to 2015 and subsequently stabilized. The overall percentage of RNA testing among anti-HCV positives was 53.1% (range, 20%-70%), which stabilized at approximately 50% after 2010. The genotyping rate for RNA positives varied between 40% and 70%. The main genotype identified was genotype 1 (85.7%).

CONCLUSION

In an ideal CHC awareness state, all anti-HCV positives should undergo RNA testing, and genotyping should be performed when RNA tests are positive. However, even in our referral center, the combined rate of RNA and genotype testing was only approximately 50% during the last 10 years.

摘要

背景/目的：慢性丙型肝炎（CHC）是唯一可以用口服抗病毒药物治疗的病毒感染。然而，CHC 意识是世界卫生组织到 2030 年消除丙型肝炎病毒（HCV）目标的主要障碍。在此，分析了土耳其哈塞特佩大学医院 2000 年 1 月至 2017 年 12 月期间 CHC 意识趋势。

材料和方法

回顾性分析了 HCV 检测结果（抗-HCV、HCV RNA、HCV 基因型）的中心实验室数据。合并 548141 份抗-HCV 检测结果后，分析了 395103 例。CHC 意识的定义如下两个参数：（1）抗-HCV 阳性者 HCV RNA 结果存在，（2）HCV RNA 阳性者基因型结果存在。

结果

抗-HCV 阳性者年龄大于阴性者（平均年龄-岁±SD，59.4±19.0 岁比 44.0±18.9 岁），女性阳性率高于男性（1.4%比 1.0%）。2000 年至 2015 年，抗-HCV 阳性率从 3.1%降至 0.6%，随后稳定。抗-HCV 阳性者中 RNA 检测的总百分比为 53.1%（范围 20%-70%），2010 年后稳定在 50%左右。RNA 阳性者的基因分型率在 40%-70%之间。鉴定的主要基因型是基因型 1（85.7%）。