Department of Pediatric Neurology, University of Turku and Turku University Hospital, P.O. Box 52, 20521, Turku, Finland.
Department of Adolescent Psychiatry, Turku University Hospital, Turku, Finland.
Pediatr Radiol. 2021 Jul;51(8):1471-1480. doi: 10.1007/s00247-021-05000-3. Epub 2021 Apr 24.
Diffusion tensor imaging is a widely used imaging method of brain white matter, but it is prone to imaging artifacts. The data corrections can affect the measured values.
To explore the impact of susceptibility correction on diffusion metrics.
A cohort of 27 healthy adolescents (18 boys, 9 girls, mean age 12.7 years) underwent 3-T MRI, and we collected two diffusion data sets (anterior-posterior). The data were processed both with and without susceptibility artifact correction. We derived fractional anisotropy, mean diffusivity and histogram data of fiber length distribution from both the corrected and uncorrected data, which were collected from the corpus callosum, corticospinal tract and cingulum bilaterally.
Fractional anisotropy and mean diffusivity values significantly differed when comparing the pathways in all measured tracts. The fractional anisotropy values were lower and the mean diffusivity values higher in the susceptibility-corrected data than in the uncorrected data. We found a significant difference in total tract length in the corpus callosum and the corticospinal tract.
This study indicates that susceptibility correction has a significant effect on measured fractional anisotropy, and on mean diffusivity values and tract lengths. To receive reliable and comparable results, the correction should be used systematically.
弥散张量成像是一种广泛应用于脑白质成像的方法，但容易产生成像伪影。数据校正会影响测量值。
探讨磁化率校正对弥散指标的影响。
本研究纳入 27 名健康青少年（男 18 名，女 9 名，平均年龄 12.7 岁），进行了 3-T MRI 检查，采集了两组弥散张量成像数据（前后向）。分别对校正和未校正数据进行处理，从双侧胼胝体、皮质脊髓束和扣带回获取各向异性分数、平均弥散度和纤维长度分布直方图数据。
在所有测量束中，校正和未校正数据的各向异性分数和平均弥散度值存在显著差异。校正后数据的各向异性分数较低，平均弥散度值较高。我们发现胼胝体和皮质脊髓束的总束长度存在显著差异。
本研究表明，磁化率校正对测量的各向异性分数、平均弥散度值和束长有显著影响。为了获得可靠且可比的结果，应系统地进行校正。
