Department of Neurology, The First Affiliated Hospital Of Harbin Medical University, No. 23 Youzheng Street, Harbin, 150001, People's Republic of China.
Department of Endocrine, The First Affiliated Hospital Of Harbin Medical University, No. 23 Youzheng Street, Harbin, 150001, People's Republic of China.
Acta Neurol Belg. 2021 Oct;121(5):1101-1110. doi: 10.1007/s13760-021-01676-4. Epub 2021 Apr 24.
Cognitive dysfunction is a degenerative disease of the central nervous system, which often associates with ageing brain as well as neurodegenerative diseases. A growing body of evidence suggests that patients with diabetes mellitus (DM) have a significantly higher risk of cognitive impairment. In recent years, studies have found that patients with diabetes-related cognitive dysfunction have an increased burden of leukoaraiosis (LA), and larger white matter hyperintensity (WMH) volume. With the recent advancement of technologies, multimodal imaging is widely exploited for the precise evaluation of central nervous system diseases. Emerging studies suggest that LA pathology can be used as a predictive signal of white matter lesions in patients with diabetes-related cognitive dysfunction, providing support for early identification and diagnosis of disease. This article reviews the findings, epidemiological characteristics, pathogenesis, imaging features, prevention and treatment of LA pathophysiology in patients with diabetes-related cognitive dysfunction.
认知功能障碍是一种中枢神经系统退行性疾病，常与衰老大脑以及神经退行性疾病相关。越来越多的证据表明，糖尿病患者（DM）发生认知障碍的风险显著增加。近年来的研究发现，与糖尿病相关的认知功能障碍患者脑白质病变（LA）负担增加，且大脑白质高信号（WMH）容积更大。随着技术的进步，多模态成像被广泛用于中枢神经系统疾病的精确评估。新出现的研究表明，LA 病理学可以作为预测糖尿病相关认知功能障碍患者脑白质病变的信号，为疾病的早期识别和诊断提供支持。本文综述了糖尿病相关认知功能障碍患者 LA 病理生理学的研究结果、流行病学特征、发病机制、影像学特征、预防和治疗。
