School of Medicine, Bam University of Medical Sciences, Bam, Iran.
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Prog Biophys Mol Biol. 2021 Sep;164:63-71. doi: 10.1016/j.pbiomolbio.2021.04.001. Epub 2021 Apr 21.
Despite significant signs of progress in cancer treatment over the past decade, either cancer prevalence or mortality continuously grow worldwide. Current anti-cancer agents show insignificant effectiveness, followed by serious side effects. It is important to find new, highly efficient pharmacological agents to increase cancer patients' clinical outcomes. Curcumin, a polyphenolic compound, has gained growing attention because of its anti-cancer properties. Curcumin can hinder the development, migration, and metastasis of cancer cells. The anti-cancer effects of curcumin are principally attributed to the regulation of several cellular signaling pathways, including MAPK/PI3K/Akt, Wnt/β-catenin, JAK/STAT, and NF-ĸB signaling pathways. Furthermore, curcumin can affect the expression and function of tumor-suppressive and oncogenic long non-coding RNAs (lncRNAs). In this study, we briefly reviewed the modulatory effect of curcumin on dysregulated tumor-supportive and tumor-suppressive lncRNAs in several cancers. It is hoped that a better understanding of curcumin's anti-cancer properties would pave the way for the development of a therapeutic approach in cancer.
尽管在过去十年中癌症治疗取得了重大进展，但癌症的患病率或死亡率仍在全球范围内持续增长。目前的抗癌药物疗效不明显，且伴随严重的副作用。寻找新的、高效的药理制剂以提高癌症患者的临床疗效非常重要。姜黄素是一种多酚化合物，由于其抗癌特性而受到越来越多的关注。姜黄素可以阻止癌细胞的发展、迁移和转移。姜黄素的抗癌作用主要归因于对几种细胞信号通路的调节，包括 MAPK/PI3K/Akt、Wnt/β-catenin、JAK/STAT 和 NF-ĸB 信号通路。此外，姜黄素可以影响肿瘤抑制和致癌长链非编码 RNA（lncRNA）的表达和功能。在本研究中，我们简要综述了姜黄素对几种癌症中失调的肿瘤支持性和肿瘤抑制性 lncRNA 的调节作用。希望更好地了解姜黄素的抗癌特性将为癌症治疗方法的发展铺平道路。
