多民族中老年人群体内 Tau 神经病理学的性别差异。
Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults.
机构信息
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY, USA.
Department of Medicine, College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
出版信息
Neurobiol Aging. 2021 Jul;103:109-116. doi: 10.1016/j.neurobiolaging.2021.03.007. Epub 2021 Mar 23.
It is unclear whether women have higher brain tau pathology. The objective of this study was to examine whether women have higher tau burden than men, and whether tau differences are independent of amyloid β (Aβ) burden. We conducted a cross-sectional analysis of a multiethnic sample of 252 nondemented late middle-aged (mean age: 64.1 years) adults with tau and amyloid Positron Emission Tomography (PET) data. Tau burden was measured as global standardized uptake value ratio (SUVR) in the middle/inferior temporal gyri and medial temporal cortex with F-MK-6240 PET. Aβ was measured as global SUVR with F-Florbetaben PET. Women had higher middle/inferior temporal gyri tau SUVR compared to men. However, no sex differences in the medial temporal cortex were observed. Women had higher brain Aβ SUVR compared to men. Continuous Aβ SUVR was positively correlated with medial temporal cortex and middle/inferior temporal gyri tau SUVR. However, there was no evidence of effect modification by Aβ SUVR on sex and tau. Compared with men, women in late middle age show higher tau burden, independent of Aβ.
尚不清楚女性的大脑 tau 病理是否更高。本研究的目的是检验女性的 tau 负担是否高于男性，以及 tau 的差异是否独立于淀粉样蛋白 β（Aβ）负担。我们对一个具有 tau 和淀粉样蛋白正电子发射断层扫描（PET）数据的多民族、252 名非痴呆中老年（平均年龄：64.1 岁）成年人的横断面进行了分析。tau 负担用 F-MK-6240 PET 测量的中/下颞回和内侧颞叶的全局标准化摄取比值（SUVR）来衡量。Aβ 用 F-Florbetaben PET 测量的全局 SUVR 来衡量。与男性相比，女性的中/下颞回 tau SUVR 更高。然而，在内侧颞叶没有观察到性别差异。与男性相比，女性的大脑 Aβ SUVR 更高。连续的 Aβ SUVR 与内侧颞叶和中/下颞回 tau SUVR 呈正相关。然而，没有证据表明 Aβ SUVR 对性别和 tau 有影响修饰作用。与男性相比，中老年女性的 tau 负担更高，独立于 Aβ。
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