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恶性外周神经鞘瘤在 Seba 的短尾蝙蝠(Carollia perspicillata)中。

Malignant Peripheral Nerve Sheath Tumour in a Seba's Short-Tailed Bat (Carollia perspicillata).

机构信息

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

出版信息

J Comp Pathol. 2021 Apr;184:72-76. doi: 10.1016/j.jcpa.2021.02.004. Epub 2021 Mar 25.

Abstract

There are few reports of tumours in bats, despite the fact that members of the Chiroptera order include 22.4% of all currently known mammal species. We now describe a case of malignant peripheral nerve sheath tumour (MPNST) in an adult female Seba's short-tailed bat (Carollia perspicillata) from a private zoo in Switzerland. The macroscopical and histological findings indicated that the MPNST originated from a dorsal spinal nerve root sheath in the lumbar region and metastasized to the spleen. Immunohistochemical labelling for glial fibrillary acid protein, S100 protein, neuron specific enolase and synaptophysin was negative. The cytoplasm of a few neoplastic cells labelled for smooth muscle actin and desmin. To our knowledge, this is the first report of a PNST in a member of the Chiroptera order.

摘要

虽然翼手目动物包括了所有已知哺乳动物物种的 22.4%,但有关蝙蝠肿瘤的报道却很少。我们现在描述了一例来自瑞士私人动物园的成年雌性塞氏短尾蝠(Carollia perspicillata)的恶性外周神经鞘瘤(MPNST)。宏观和组织学发现表明,MPNST 起源于腰椎的背根神经鞘,并转移到脾脏。胶质纤维酸性蛋白、S100 蛋白、神经元特异性烯醇化酶和突触素的免疫组织化学标记为阴性。少数肿瘤细胞的细胞质标记为平滑肌肌动蛋白和结蛋白。据我们所知,这是翼手目动物中首例报道的周围神经鞘瘤。

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