NS1 抗体如何预防重症黄病毒病。

How NS1 Antibodies Prevent Severe Flavivirus Disease.

机构信息

Programme in Emerging Infectious Disease, Duke-National University of Singapore Medical School, Singapore 169857, Singapore; Center for BioImaging Sciences, National University of Singapore, Singapore 117557, Singapore; Department of Biological Sciences, National University of Singapore, Singapore 117557, Singapore.

出版信息

Trends Biochem Sci. 2021 Jul;46(7):519-521. doi: 10.1016/j.tibs.2021.03.005. Epub 2021 Apr 22.

DOI:10.1016/j.tibs.2021.03.005

PMID:33895084

Abstract

The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.

摘要

黄病毒属包括几种主要的人类病原体，包括登革热（DENV）和寨卡病毒。黄病毒非结构蛋白 1（NS1）在疾病进展中起着重要作用，例如在重症登革热的发展中。抗 NS1 抗体已被证明具有保护作用，Biering 等人和 Modhiran 等人的两项关于 NS1：抗体复合物结构的新研究揭示了它们的中和机制。