Ghonimi Nesma A M, Elsharkawi Khaled A, Khyal Doaa S M, Abdelghani Alaa A
Neurology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Neurology Department, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Mult Scler Relat Disord. 2021 Jun;51:102941. doi: 10.1016/j.msard.2021.102941. Epub 2021 Apr 9.
Introduction Oxidative stress has been suggested to play a key role in pathogenesis of multiple sclerosis (MS), but clinical data on oxidative stress markers in MS patients and their influence on clinical and radiologic characteristics of the disease are inconsistent. The aim of this study is to assess the serum levels of malondialdehyde (MDA) as a measure of lipid peroxidation in MS patients and its relation to disease characteristics. Methods This case control study included 120 patients with clinically definite relapsing remitting multiple sclerosis (RRMS) compared to 120 age and sex -matched healthy controls. MDA levels were measured using thiobarbituric acid reactive substances (TBARS) assay. Results MDA levels are significantly higher in patients with MS than those in control (P<0.001) especially during relapse, MDA levels are higher in patients taking no disease modifying therapy (DMT) than those taking interferon (IFN-β). MDA levels significantly correlate with expanded disability status scale (EDSS) (P<0.001). Conclusions The results of this study can provide evidence about the incrimination of oxidative stress in MS pathogenesis and disease disability and support the use of antioxidants as a new target of treatment that focuses on neutralizing free radicals and increases antioxidant capacity.
引言 氧化应激被认为在多发性硬化症（MS）的发病机制中起关键作用，但关于MS患者氧化应激标志物的临床数据及其对该疾病临床和影像学特征的影响并不一致。本研究的目的是评估丙二醛（MDA）的血清水平，作为MS患者脂质过氧化的指标，并探讨其与疾病特征的关系。方法 本病例对照研究纳入了120例临床确诊的复发缓解型多发性硬化症（RRMS）患者，并与120例年龄和性别匹配的健康对照进行比较。采用硫代巴比妥酸反应物质（TBARS）法测定MDA水平。结果 MS患者的MDA水平显著高于对照组（P<0.001），尤其是在复发期间。未接受疾病修饰治疗（DMT）的患者MDA水平高于接受干扰素（IFN-β）治疗的患者。MDA水平与扩展残疾状态量表（EDSS）显著相关（P<0.001）。结论 本研究结果可为氧化应激参与MS发病机制和疾病残疾提供证据，并支持将抗氧化剂作为一种新的治疗靶点，其重点在于中和自由基并提高抗氧化能力。
