Kurdistan Board of Medical Specialties (KBMS), Kurdistan Region, Iraq.
Department of Medical Analysis, Faculty of Science, Tishk International University - Erbil, Kurdistan Region, Iraq.
Mult Scler Relat Disord. 2021 Nov;56:103228. doi: 10.1016/j.msard.2021.103228. Epub 2021 Aug 28.
Multiple sclerosis (MS), as a neurodegenerative disorder, exhibits inflammation and oxidative stress hallmarks.
The research aims to know any disturbances in haematological parameters and antioxidant system of relapsing-remitting multiple sclerosis (RRMS) patients in the Kurdish population.
A case-control research meeting following the McDonald criterion was conducted on 100 RRMS patients and 100 controls.
Lipid peroxidation products of malondialdehyde (MDA), erythrocyte sedimentation rate (ESR), and total leucocyte counts (TLCs) were increased significantly, but copper (Cu+2) and superoxide dismutase (SOD) were decreased significantly while nitric oxide metabolites (NOx) and lymphocyte were not changed significantly if compared with that of controls.
Findings from our study revealed that some defects were detected in haematological profiles in the Kurdish population and disturbance of immunological parameters. In addition, the utilization of Cu+2 supplement as an effective modality for RRMS patients may be beneficial.
多发性硬化症（MS）作为一种神经退行性疾病，表现出炎症和氧化应激的特征。
本研究旨在了解库尔德人群中复发缓解型多发性硬化症（RRMS）患者的血液学参数和抗氧化系统是否存在紊乱。
对 100 例 RRMS 患者和 100 例对照进行了病例对照研究，符合 McDonald 标准。
与对照组相比，丙二醛（MDA）、红细胞沉降率（ESR）和总白细胞计数（TLCs）的脂质过氧化产物显著增加，而铜（Cu+2）和超氧化物歧化酶（SOD）显著减少，而一氧化氮代谢物（NOx）和淋巴细胞则无明显变化。
本研究结果表明，在库尔德人群中发现了血液学特征的一些缺陷和免疫参数的紊乱。此外，补充 Cu+2 可能对 RRMS 患者有益。
