Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Department of Pulmonary Medicine, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Lung Cancer. 2021 Jun;156:72-75. doi: 10.1016/j.lungcan.2021.04.015. Epub 2021 Apr 16.
NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered.
We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS.
On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma.
This entity represents a novel subtype of non-small cell lung cancer, which we would like to term 'ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma'.
NTRK 融合基因已在多种实体肿瘤中被发现，包括 NSCLC 和肉瘤。新的 NTRK 易位相关肿瘤仍在不断被发现。
我们报告了一例 49 岁患者，其左肺下叶有一个肿块，已行切除术。该标本通过靶向 DNA 下一代测序（NGS）和锚定多重-PCR（AMP）靶向 RNA NGS 进行分析和测序。
在病理评估中，发现一种具有独特形态的支气管周围黏液性肿瘤。RNA NGS 分析显示在低度黏液性支气管腺癌中存在 ETV6-NTRK3 易位。
该实体代表一种新型非小细胞肺癌亚型，我们将其命名为“ETV6-NTRK3 易位相关低度黏液性支气管腺癌”。
