ETV6-NTRK3 易位相关的低级别黏液性支气管腺癌：一种新型的支气管涎腺型非小细胞肺癌亚型。
ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma: A novel bronchial salivary gland-type non-small cell lung cancer subtype.
机构信息
Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
Department of Pulmonary Medicine, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
出版信息
Lung Cancer. 2021 Jun;156:72-75. doi: 10.1016/j.lungcan.2021.04.015. Epub 2021 Apr 16.
INTRODUCTION
NTRK fusion genes have been found in several solid tumors, among which NSCLC and sarcoma. Novel NTRK translocation-related tumors are still being discovered.
METHODS
We report a 49-year-old patient with a mass in the left lower lung lobe that was resected. This specimen was analyzed and sequenced using targeted DNA next generation sequencing (NGS) and anchored-multiplex-PCR (AMP) targeted RNA NGS.
RESULTS
On pathological evaluation, a peribronchial mucinous neoplasm with a unique morphology was found. RNA NGS analysis showed anETV6-NTRK3 translocation in a low-grade mucinous bronchial adenocarcinoma.
CONCLUSIONS
This entity represents a novel subtype of non-small cell lung cancer, which we would like to term 'ETV6-NTRK3 translocation-associated low-grade mucinous bronchial adenocarcinoma'.
简介
NTRK 融合基因已在多种实体肿瘤中被发现，包括 NSCLC 和肉瘤。新的 NTRK 易位相关肿瘤仍在不断被发现。
方法
我们报告了一例 49 岁患者，其左肺下叶有一个肿块，已行切除术。该标本通过靶向 DNA 下一代测序（NGS）和锚定多重-PCR（AMP）靶向 RNA NGS 进行分析和测序。
结果
在病理评估中，发现一种具有独特形态的支气管周围黏液性肿瘤。RNA NGS 分析显示在低度黏液性支气管腺癌中存在 ETV6-NTRK3 易位。
结论
该实体代表一种新型非小细胞肺癌亚型，我们将其命名为“ETV6-NTRK3 易位相关低度黏液性支气管腺癌”。
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