早期生活中接触中国饥荒、成年期肥胖模式与高血压发病的关系：一项长达 22 年的队列研究。

Exposure to Chinese Famine in the Early Life, Adulthood Obesity Patterns, and the Incidence of Hypertension: A 22-Year Cohort Study.

机构信息

Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.

Medical Department, The Fifth Central Hospital of Tianjin, Tianjin, China.

出版信息

Ann Nutr Metab. 2021;77(2):109-115. doi: 10.1159/000515060. Epub 2021 Apr 23.

DOI:10.1159/000515060

PMID:33895740

Abstract

INTRODUCTION

Little is known regarding the joint associations of famine exposure and obesity patterns with the incidence of hypertension.

METHODS

We defined famine exposure cohorts as follows: nonexposure (born between 1962 and 1965), fetal life exposure (born between 1959 and 1961), early childhood exposure (born between 1956 and 1958), midchildhood exposure (born between 1953 and 1955), and late childhood exposure (born between 1949 and 1952). Obesity patterns were defined as follows: G-/A-: subjects without neither general obesity nor abdominal obesity; G+/A- or G-/A+: subjects with either general obesity or abdominal obesity; G+/A+: subjects with both general obesity and abdominal obesity. Hypertension was defined as systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg or current treatment with antihypertensive medications.

RESULTS

There were 5,235 individuals participating in this study. In the subjects with general or abdominal obesity, famine exposure was associated with a lower risk of hypertension. In males with G-/A-, famine exposures in the midchildhood (p = 0.048; HR: 0.700; HR 95% CI: 0.491-0.998) and late childhood (p = 0.002; HR: 0.560; HR 95% CI: 0.374-0.840) were associated with a lower incidence of hypertension.

CONCLUSION

The coexistence of famine exposure and obesity patterns was associated with the incidence of hypertension.

摘要

简介

关于饥荒暴露和肥胖模式与高血压发病率的联合关联，人们知之甚少。

方法

我们将饥荒暴露队列定义为：无暴露（出生于 1962 年至 1965 年之间）、胎儿期暴露（出生于 1959 年至 1961 年之间）、幼儿期暴露（出生于 1956 年至 1958 年之间）、儿童中期暴露（出生于 1953 年至 1955 年之间）和儿童晚期暴露（出生于 1949 年至 1952 年之间）。肥胖模式定义如下：G-/A-：既没有一般肥胖也没有腹部肥胖的受试者；G+/A-或 G-/A+：有一般肥胖或腹部肥胖的受试者；G+/A+：有一般肥胖和腹部肥胖的受试者。高血压定义为收缩压≥140mmHg 和/或舒张压≥90mmHg 或正在服用抗高血压药物。

结果

共有 5235 人参与了这项研究。在有一般或腹部肥胖的受试者中，饥荒暴露与较低的高血压风险相关。在 G-/A-的男性中，儿童中期（p=0.048；HR：0.700；HR95%CI：0.491-0.998）和儿童晚期（p=0.002；HR：0.560；HR95%CI：0.374-0.840）的饥荒暴露与较低的高血压发病率相关。