早年间暴露于中国饥荒与成年后患代谢综合征风险之间的关联。
Association of Exposure to Chinese Famine in Early Life with the Risk of Metabolic Syndrome in Adulthood.
机构信息
Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.
Department of Epidemiology and Statistics, School of Public Health, Tianjin Medical University, Tianjin, China,
出版信息
Ann Nutr Metab. 2020;76(2):140-146. doi: 10.1159/000507356. Epub 2020 Apr 7.
OBJECTIVE
To explore the association of famine exposure in early life with the risk of metabolic syndrome (MS) in the -Chinese adults.
METHODS
Data were obtained from the wave 2009 of the China Health and Nutrition Survey. MS was identified when 3 or more of the following components happened: (1) waist circumference >90 cm in males or >85 cm in females; (2) fasting glucose ≥6.1 mmol/L; (3) systolic blood pressure ≥130 mm Hg/diabolic blood pressure ≥85 mm Hg; (4) fasting triglyceride ≥1.70 mmol/L; and (5) high-density lipids cholesterol <1.04 mmol/L. All participants were divided into 5 groups: no exposure, born after 1961; fetal life exposure, between 1959 and 1961; early childhood exposure, between 1956 and 1958; mid-childhood exposure, between 1953 and 1955; and late childhood exposure, between 1949 and 1952. A total of 2,080 subjects were included in this study.
RESULTS
In rural, famine exposure in fetal life and early childhood was associated with the lower risk of MS (p = 0.0491 and 0.0245; OR 0.583 and 0.703; and OR, 95% CI 0.341-0.998 and 0.517-0.956, respectively). But famine exposure in late childhood was associated with the higher risk of MS (p = 0.0140; OR 3.096; and OR, 95% CI 1.257-7.625). Famine exposure in early childhood was associated with the lower risk of MS (p = 0.0120; OR 0.633; and OR, 95% CI 0.443-0.904) in males.
CONCLUSIONS
Famine exposure in mid- and late-childhood was associated with the higher risk of MS, especially in rural, males, and severe famine areas.
目的
探讨生命早期饥荒暴露与中国成年人代谢综合征（MS）风险的关系。
方法
数据来自中国健康与营养调查 2009 年的第 2 波调查。当以下 3 个或以上成分发生时，将 MS 定义为：（1）男性腰围>90 cm 或女性腰围>85 cm；（2）空腹血糖≥6.1 mmol/L；（3）收缩压≥130 mmHg/diabolic 血压≥85 mm Hg；（4）空腹甘油三酯≥1.70 mmol/L；和（5）高密度脂蛋白胆固醇<1.04 mmol/L。所有参与者被分为 5 组：无暴露组，出生于 1961 年后；胎儿期暴露组，1959 年至 1961 年期间；幼儿期暴露组，1956 年至 1958 年期间；儿童中期暴露组，1953 年至 1955 年期间；和儿童晚期暴露组，1949 年至 1952 年期间。本研究共纳入 2080 名受试者。
结果
在农村地区，胎儿期和幼儿期的饥荒暴露与 MS 风险降低相关（p = 0.0491 和 0.0245；OR 0.583 和 0.703；OR，95%CI 0.341-0.998 和 0.517-0.956）。但儿童晚期的饥荒暴露与 MS 风险增加相关（p = 0.0140；OR 3.096；OR，95%CI 1.257-7.625）。在男性中，幼儿期的饥荒暴露与 MS 风险降低相关（p = 0.0120；OR 0.633；OR，95%CI 0.443-0.904）。
结论
儿童中期和晚期的饥荒暴露与 MS 风险增加相关，尤其是在农村地区、男性和严重饥荒地区。
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