Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fetal Diagn Ther. 2021;48(5):333-341. doi: 10.1159/000514327. Epub 2021 Apr 23.
To retrospectively investigate the feasibility of magnetic resonance virtual endoscopy (MRVE) to visualize the normal limbs and limb deformities Methods: MR sequences included two-dimensional (2D) single fast spin-echo sequence and 2D and 3D steady-state procession fast imaging sequences. MRVE reconstruction was retrospectively performed by 2 radiologists in 32 fetuses in 30 pregnant women. The correlation between the radiologists for the virtual endoscopy threshold of MRVE was determined. Image quality and limb segment visibility were independently rated. Area under the receiver operating characteristics curve (AUC) of 2D MRI and MRVE was calculated.
The mean virtual endoscopy threshold required for the visualization of the limb was 991.93 ± 12.13 and 991.83 ± 12.26 for 2 radiologists, respectively. The correlation between the radiologists for virtual endoscopy threshold was excellent (r = 0.933). The weighted kappa statistic was 0.96 for the evaluation of image quality of limb segments, indicating excellent interobserver agreement. Compared to that of 2D MRI alone, a higher AUC of 2D MRI with MRVE was achieved in detection of both upper and lower limb deformities (0.91 vs. 0.69 and 0.83 vs. 0.71, respectively).
MRVE may display normal and abnormal fetal limb orientation and structures from multiple perspectives and provide incremental information for obstetrics.
回顾性研究磁共振虚拟内镜（MRVE）可视化正常肢体和肢体畸形的可行性。
MR 序列包括二维（2D）单快速自旋回波序列和 2D 和 3D 稳态快速成像序列。30 名孕妇的 32 名胎儿由 2 名放射科医生进行 MRVE 重建。确定了放射科医生对虚拟内镜 MRVE 阈值的相关性。独立评估图像质量和肢体节段的可视性。计算二维 MRI 和 MRVE 的受试者工作特征曲线下面积（AUC）。
2 名放射科医生分别为可视化肢体所需的虚拟内镜阈值的平均值为 991.93 ± 12.13 和 991.83 ± 12.26。放射科医生之间的相关性为优秀（r = 0.933）。肢体节段图像质量评估的加权 kappa 统计量为 0.96，表明观察者间具有极好的一致性。与单独使用二维 MRI 相比，二维 MRI 与 MRVE 联合检测上下肢畸形的 AUC 更高（0.91 与 0.69 和 0.83 与 0.71）。
MRVE 可以从多个角度显示正常和异常胎儿肢体的方位和结构，并为产科提供额外的信息。
