Wang Kyu-Chang
Neuro-oncology Clinic, Center for Rare Cancers, National Cancer Center, Goyang, Korea.
J Korean Neurosurg Soc. 2021 May;64(3):414-417. doi: 10.3340/jkns.2021.0040. Epub 2021 Apr 26.
During the last two decades, there have been remarkable advances in knowledge regarding secondary neurulation. An increased number of cases of occult spinal dysraphism and progress in basic embryology research have provoked the continuous discovery of new disease entities and the reclassification of occult spinal dysraphic lesions. Examples of such changes are described. The characteristics of secondary neurulation compared with those of primary neurulation are listed and discussed. Our fundamental questions include what the evolutionary significance of secondary neurulation is and what the advantages of having secondary neurulation are. However, our current data and speculations are insufficient to support scientific inference. The direction of future progress of research in this field is predicted. The role of clinicians in this progress is emphasized.
在过去二十年中，关于继发性神经管形成的知识取得了显著进展。隐性脊柱裂病例数量的增加以及基础胚胎学研究的进展促使新疾病实体不断被发现，隐性脊柱裂病变也得以重新分类。文中描述了此类变化的实例。列出并讨论了继发性神经管形成与原发性神经管形成相比的特征。我们的基本问题包括继发性神经管形成的进化意义是什么以及拥有继发性神经管形成的优势是什么。然而，我们目前的数据和推测不足以支持科学推断。预测了该领域未来研究的进展方向。强调了临床医生在这一进展中的作用。
