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过去二十年的脊柱裂:动态进步时代的所见所闻

Spinal Dysraphism in the Last Two Decades : What I Have Seen during the Era of Dynamic Advancement.

作者信息

Wang Kyu-Chang

机构信息

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.

出版信息

J Korean Neurosurg Soc. 2020 May;63(3):272-278. doi: 10.3340/jkns.2020.0068. Epub 2020 Apr 27.

DOI:10.3340/jkns.2020.0068
PMID:32336058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7218192/
Abstract

Compared to any other decade, the last two decades have been the most dynamic period in terms of advances in the knowledge on spinal dysraphism. Among the several factors of rapid advancement, such as embryology during secondary neurulation and intraoperative neurophysiological monitoring, there is no doubt that Professor Dachling Pang stood high amidst the period. I review here the last two decades from my personal point of view on what has been achieved in the field of spinal dysraphism, focusing on occult tethered cord syndrome, lumbosacral lipomatous malformation, terminal myelocystocele, retained medullary cord, limited dorsal myeloschisis and junctional neural tube defect. There are still many issues to revise, add and extend. Profound knowledge of basic science is critical, as well as refined clinical analysis. I expect that young scholars who follow the footsteps of precedent giants will shed bright light on this topic in the future.

摘要

与其他任何十年相比,过去二十年是脊柱裂相关知识进展最为活跃的时期。在快速发展的诸多因素中,如继发神经胚形成过程中的胚胎学以及术中神经生理监测等,毫无疑问,达克林·庞教授在这一时期脱颖而出。在此,我从个人角度回顾过去二十年脊柱裂领域所取得的成就,重点关注隐匿性脊髓拴系综合征、腰骶部脂肪瘤样畸形、终丝脊髓囊肿、脊髓残留、局限性脊髓脊膜膨出和交界性神经管缺陷。仍有许多问题需要修正、补充和拓展。扎实的基础科学知识以及精细的临床分析至关重要。我期待追随前辈巨人脚步的年轻学者未来能为这一主题带来新的曙光。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/5141ac1655aa/jkns-2020-0068f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/4d8de49f2b44/jkns-2020-0068f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/aee453896303/jkns-2020-0068f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/5141ac1655aa/jkns-2020-0068f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/4d8de49f2b44/jkns-2020-0068f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/aee453896303/jkns-2020-0068f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da7/7218192/5141ac1655aa/jkns-2020-0068f3.jpg

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引用本文的文献

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2
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Adv Tech Stand Neurosurg. 2022;45:285-315. doi: 10.1007/978-3-030-99166-1_9.
3
Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis.继发性神经管形成障碍:主要聚焦于病理胚胎发生

本文引用的文献

1
Do junctional neural tube defect and segmental spinal dysgenesis have the same pathoembryological background?交界性神经管缺陷和节段性脊柱发育不良是否具有相同的病理胚胎学背景?
Childs Nerv Syst. 2020 Feb;36(2):241-250. doi: 10.1007/s00381-019-04425-4. Epub 2019 Dec 10.
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Limited Dorsal Myeloschisis: Reconsideration of its Embryological Origin.局限性背侧脊髓脊膜膨出:胚胎起源的再思考。
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Congenital Dermal Sinus and Limited Dorsal Myeloschisis: "Spectrum Disorders" of Incomplete Dysjuction Between Cutaneous and Neural Ectoderms.
J Korean Neurosurg Soc. 2021 May;64(3):386-405. doi: 10.3340/jkns.2021.0023. Epub 2021 Apr 29.
先天性皮肤窦和有限的背侧脊髓脊膜膨出:表皮外胚层和神经外胚层不完全分离的“谱系障碍”。
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Unjoined primary and secondary neural tubes: junctional neural tube defect, a new form of spinal dysraphism caused by disturbance of junctional neurulation.原发性和继发性神经管未连接:交界性神经管缺陷,一种由交界性神经胚形成障碍引起的新型脊柱裂。
Childs Nerv Syst. 2017 Oct;33(10):1633-1647. doi: 10.1007/s00381-016-3288-7. Epub 2016 Oct 29.
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Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects.节段性神经管形成:一种独特的发育程序,塑造脊髓中一个对神经管缺陷高度敏感的离散区域。
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Childs Nerv Syst. 2013 Sep;29(9):1683-8. doi: 10.1007/s00381-013-2196-3. Epub 2013 Jun 19.
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