Kiani Ali Asghar, Elyasi Hossein, Ghoreyshi Shadiyeh, Nouri Negar, Safarzadeh Ali, Nafari Amirhossein
Department of Laboratory Sciences, Lorestan University of Medical Sciences, Khoramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khoramabad, Iran.
Immunol Med. 2021 Dec;44(4):223-236. doi: 10.1080/25785826.2021.1910187. Epub 2021 Apr 25.
The Hypoxia-Inducible Factor-1 (HIF-1) is a dimeric protein complex that plays a significant role in responding to low oxygen or hypoxia concentrations. Chronic inflammation is one of the immune system responses and can increase HIF expression in involved tissues through lowering the oxygen and hypoxia. The HIF factor has many critical roles in immunity, and thus, we reviewed the crucial roles of this factor in the immune system. The results showed various key roles on the immune system, including physical defenses, innate immune (neutrophils apoptosis, macrophages) and inflammatory responses (pyrexia and local heat, iron access, etc.), upregulation in response to microbial infections, cytokines expression (IL-1, IL-2, IL-6, IL-8, IL-12, IL-18, TNF, etc.), drug targeting, etc. The HIF roles in the acquired immune system include: enhance the adaptation of cells (dendritic cells) to new conditions and triggering the signal pathways. The findings of the present review demonstrated that the HIF has important roles in the immune system, including physical defense, innate immune as well as acquired immunity; therefore, it may be considered as a potent drug targeting several diseases such as cancers, infectious diseases, etc.
缺氧诱导因子-1（HIF-1）是一种二聚体蛋白复合物，在应对低氧或缺氧浓度时发挥重要作用。慢性炎症是免疫系统的反应之一，可通过降低氧气含量和造成缺氧来增加受累组织中HIF的表达。HIF因子在免疫中具有许多关键作用，因此，我们综述了该因子在免疫系统中的关键作用。结果显示其在免疫系统中具有多种关键作用，包括物理防御、固有免疫（中性粒细胞凋亡、巨噬细胞）和炎症反应（发热和局部发热、铁的获取等）、对微生物感染的反应上调、细胞因子表达（白细胞介素-1、白细胞介素-2、白细胞介素-6、白细胞介素-8、白细胞介素-12、白细胞介素-18、肿瘤坏死因子等）、药物靶向等。HIF在获得性免疫系统中的作用包括：增强细胞（树突状细胞）对新环境的适应性并触发信号通路。本综述的研究结果表明，HIF在免疫系统中具有重要作用，包括物理防御、固有免疫以及获得性免疫；因此，它可能被视为针对多种疾病（如癌症、传染病等）的有效药物靶点。
