对斯普拉格-道利大鼠经吸入给予偏二氯乙烯的长期致癌性生物测定。新结果。

Long-term carcinogenicity bioassay on vinylidene chloride administered by inhalation to Sprague-Dawley rats. New results.

作者信息

Cotti G, Maltoni C, Lefemine G

机构信息

Institute of Oncology, F. Addarii, Bologna, Italy.

出版信息

Ann N Y Acad Sci. 1988;534:160-8. doi: 10.1111/j.1749-6632.1988.tb30109.x.

DOI:10.1111/j.1749-6632.1988.tb30109.x

PMID:3389653

Abstract

Vinylidene chloride was administered by inhalation, 7 hours daily, 5 days weekly, at the concentration of 100 and 0 ppm, to Sprague-Dawley rats. The treatment was started on 13-week-old breeders, and male and female offspring (12-day embryos). The breeders and some of the offspring were exposed for 104 weeks; the other offspring were exposed for 15 weeks only. An increased incidence was found of malignant tumors and of leukemias, particularly in offspring treated for 104 weeks.

摘要

将偏二氯乙烯以100 ppm和0 ppm的浓度通过吸入方式给予斯普拉格-道利大鼠，每天7小时，每周5天。治疗从13周龄的种鼠以及雄性和雌性后代（12天龄胚胎）开始。种鼠和部分后代暴露104周；其他后代仅暴露15周。发现恶性肿瘤和白血病的发病率增加，特别是在接受104周治疗的后代中。