神经肿瘤急症。

Neuro-Oncologic Emergencies.

机构信息

Division of Neurocritical Care, Department of Neurology, Stanford University School of Medicine, 300 Pasteur Drive MC 5778, Stanford, CA 94305, USA.

Division of Neurohospitalist Medicine, Department of Neurology, Stanford University School of Medicine, 453 Quarry Rd, 2nd Floor, Stanford, CA 94305, USA.

出版信息

Neurol Clin. 2021 May;39(2):545-563. doi: 10.1016/j.ncl.2021.01.012. Epub 2021 Mar 31.

DOI:10.1016/j.ncl.2021.01.012

PMID:33896532

Abstract

Cancer and cancer therapies have the potential to affect the nervous system in a host of different ways. Cerebral edema, increased intracranial pressure, cerebrovascular events, status epilepticus, and epidural spinal cord compression are among those most often presenting as emergencies. Neurologic side-effects of cancer therapies are often mild, but occasionally result in serious illness. Immunotherapies cause autoimmune-related neurologic side-effects that are generally responsive to immunosuppressive therapies. Emergency management of neuro-oncologic problems benefits from early identification and close collaboration among interdisciplinary team members and patients or surrogate decision-makers.

摘要

癌症及其治疗方法可能以多种不同方式影响神经系统。脑水肿、颅内压增高、脑血管事件、癫痫持续状态和硬脊膜外脊髓压迫症是最常表现为急症的几种情况。癌症治疗的神经副作用通常较轻，但偶尔会导致严重疾病。免疫疗法会引起与自身免疫相关的神经副作用，这些副作用通常对免疫抑制疗法有反应。神经肿瘤急症的处理得益于多学科团队成员、患者或替代决策人之间的早期识别和密切协作。