Kobayashi Mio, Yoshida Toshinori, Yamashita Risako, Ichikawa Rho, Nakahara Junta, Nakamura Kazuki, Okano Hiromu, Takahashi Yasunori, Ito Nanao, Shibutani Makoto
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Hirakawa Zoological Park, 5669-1 Hirakawa-cho, Kagoshima-shi, Kagoshima 891-0133, Japan.
J Vet Med Sci. 2021 Jul 10;83(6):994-996. doi: 10.1292/jvms.20-0709. Epub 2021 Apr 26.
We encountered a case of cutaneous squamous cell carcinoma (SCC) in a 17-year-old female koala at a zoo. A fragile, papillary, elevated mass was found on the third digit of the right hind limb. SCC was identified histopathologically: squamous cell-like polygonal tumor cells showed a nest-like growth pattern with epidermal down growth, central keratinization and necrotic foci, and invaded dermal connective tissues. Metastatic lesions were observed in various organs, including the lung and axillary lymph node: in the lung, multiple metastatic foci similar to the primary lesion, and in the axillary lymph node, individual polygonal tumor cells infiltrated the sinusoids. Immunohistochemistry revealed that the tumor cells were positive for proliferating cell nuclear antigen, which exhibited 32-33% of labeling indices in the tumor cells. To our knowledge, this is the first report of a case of SCC in a digit of a koala.
我们在一家动物园里遇到了一只17岁雌性考拉患皮肤鳞状细胞癌（SCC）的病例。在右后肢的第三趾上发现了一个脆弱、乳头状、隆起的肿块。通过组织病理学鉴定为SCC：鳞状细胞样多边形肿瘤细胞呈巢状生长模式，伴有表皮向下生长、中央角化和坏死灶，并侵犯真皮结缔组织。在包括肺和腋窝淋巴结在内的各个器官中观察到转移病灶：在肺中，有多个类似于原发灶的转移灶，在腋窝淋巴结中，单个多边形肿瘤细胞浸润到血窦中。免疫组织化学显示肿瘤细胞增殖细胞核抗原呈阳性，肿瘤细胞中的标记指数为32%-33%。据我们所知，这是首例关于考拉趾部SCC病例的报告。
