Antonsson Annika, McMillan Nigel A J
Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia.
J Gen Virol. 2006 Nov;87(Pt 11):3195-3200. doi: 10.1099/vir.0.82195-0.
Papillomaviruses are a group of ubiquitous viruses that are often found in normal skin of humans, as well as a range of different vertebrates. In this study, swab samples collected from the healthy skin of 225 Australian animals from 54 species were analysed for the presence of papillomavirus DNA with the general skin papillomavirus primer pair FAP59/FAP64. A total of five putative and potential new animal papillomavirus types were identified from three different animal species. The papillomaviruses were detected in one monotreme and two marsupial species: three from koalas, and one each from an Eastern grey kangaroo and an echidna. The papillomavirus prevalence in the three species was 14 % (10/72) in koalas, 20 % (1/5) in echidnas and 4 % (1/23) in Eastern grey kangaroos. Phylogenetic analysis was performed on the putative koala papillomavirus type that could be cloned and it appears in the phylogenetic tree as a novel putative papillomavirus genus. The data extend the range of species infected by papillomaviruses to the most primitive mammals: the monotremes and the marsupials.
乳头瘤病毒是一类普遍存在的病毒，常存在于人类以及一系列不同脊椎动物的正常皮肤中。在本研究中，使用通用皮肤乳头瘤病毒引物对FAP59/FAP64，对从54个物种的225只澳大利亚动物的健康皮肤采集的拭子样本进行分析，以检测乳头瘤病毒DNA的存在。从三种不同的动物物种中总共鉴定出五种假定的和潜在的新型动物乳头瘤病毒类型。在一种单孔目动物和两种有袋类动物中检测到了乳头瘤病毒：三种来自考拉，一种来自东部灰袋鼠，一种来自针鼹。这三种物种中乳头瘤病毒的流行率分别为：考拉14%（10/72），针鼹20%（1/5），东部灰袋鼠4%（1/23）。对可克隆的假定考拉乳头瘤病毒类型进行了系统发育分析，它在系统发育树中表现为一个新的假定乳头瘤病毒属。这些数据将乳头瘤病毒感染的物种范围扩展到了最原始的哺乳动物：单孔目动物和有袋类动物。
