Khan Imran, Ahmad Tanveer, Manzoor Nikhat, Rizvi Moshahid Alam, Raza Uqba, Premchandani Shubhangi
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
Department of Biosciences, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi, India.
Natl J Maxillofac Surg. 2020 Jul-Dec;11(2):169-175. doi: 10.4103/njms.NJMS_161_20. Epub 2020 Dec 16.
Human oral cavity is home to a number of organisms, being one of them. This review article aims at understanding the correlation between the oral candidal colonization and the local host factors that may influence it with special emphasis on congenital craniofacial anomalies such as cleft lip and palate (CLP). Various scientific databases were searched online and relevant articles were selected based on the inclusion criteria. A comparative study was done to understand the interdependence of various factors (including CLP) and oral candidal colonization. The results revealed a strong association of certain local host factors which may influence the oral colonization of species. Factors such as mucosal barrier, salivary constituents and quantity of saliva, congenital deformities like CLP, oral prostheses such as dentures/palatal obturators and fixed orthodontic appliances (FOAs) were identified. All these factors may directly affect the growth of in the oral cavity. Although numerous studies have pointed a positive correlation between Oral Candidal colonization and local host factors such as oral prostheses, FOA, and oral mucosal barrier only one study has been done, in the Indian subcontinent with respect to the correlation of candidal colonization and CLP. After the evaluation of all the factors mentioned in various case studies, it can be concluded that the presence of local host factors such as orofacial clefts, dental prostheses, FOA, xerostomia, and atrophy of the oral mucous membrane lead to significant increase in candidal colonization, but since very few studies in regard to CLP have been done worldwide and in India, in particular, further studies are warranted.
人类口腔是多种微生物的栖息地， 就是其中之一。这篇综述文章旨在了解口腔念珠菌定植与可能影响其的局部宿主因素之间的相关性，特别强调先天性颅面畸形，如唇腭裂（CLP）。通过在线搜索各种科学数据库，并根据纳入标准选择相关文章。进行了一项比较研究，以了解各种因素（包括CLP）与口腔念珠菌定植之间的相互依存关系。结果显示某些局部宿主因素与 物种的口腔定植之间存在密切关联。确定了诸如黏膜屏障、唾液成分和唾液量、像CLP这样的先天性畸形、假牙/腭阻塞器等口腔修复体以及固定正畸矫治器（FOA）等因素。所有这些因素都可能直接影响口腔中 的生长。尽管众多研究指出口腔念珠菌定植与口腔修复体、FOA和口腔黏膜屏障等局部宿主因素之间存在正相关，但在印度次大陆，关于念珠菌定植与CLP相关性的研究仅有一项。在评估各种案例研究中提到的所有因素后，可以得出结论，口面部裂隙、假牙、FOA、口干症和口腔黏膜萎缩等局部宿主因素的存在会导致念珠菌定植显著增加，但由于全球范围内，特别是在印度，关于CLP的研究非常少，因此有必要进一步开展研究。
