Machorowska-Pieniążek Agnieszka, Mertas Anna, Skucha-Nowak Małgorzata, Tanasiewicz Marta, Morawiec Tadeusz
Department of Orthodontics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Traugutta Square 2, 41-800 Zabrze, Poland.
Department of Microbiology and Immunology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, Jordana 19, 41-808 Zabrze, Poland.
Biomed Res Int. 2017;2017:1460243. doi: 10.1155/2017/1460243. Epub 2017 Mar 14.
Few reports have been published on the early microbiota in infants with various types of cleft palate. We assessed the formation of the oral microbiota in infants with complete cleft lip and palate (CLP = 30) or cleft soft palate (CSP = 25) in the neonatal period (T1 time) and again in the gum pad stage (T2 time). Culture swabs from the tongue, palate, and/or cleft margin at T1 and T2 were taken. We analysed the prevalence of the given bacterial species (the percentage) and the proportions in which the palate and tongue were colonised by each microorganism. At T1, were the most frequently detected in subjects with CLP or CSP (63% and 60%, resp.). A significantly higher frequency of methicillin-sensitive ( MSSA) was observed in CLP compared to the CSP group. At T2, significantly higher percentages of , MSSA, , and members of the Enterobacteriaceae family were noted in CLP infants compared to the CSP. and appeared with the greatest frequency on the tongue, whereas was predominant on the palate. The development of the microbiota in CLP subjects was characterised by a significant increase in the prevalence of pathogenic bacteria.
关于各类腭裂婴儿早期微生物群的报道较少。我们评估了完全性唇腭裂（CLP，n = 30）或软腭裂（CSP，n = 25）婴儿在新生儿期（T1时间）以及牙龈垫期（T2时间）口腔微生物群的形成情况。在T1和T2时间采集舌、腭和/或腭裂边缘的培养拭子。我们分析了特定细菌种类的患病率（百分比）以及每种微生物在腭和舌上的定植比例。在T1时，[具体细菌名称1]在CLP或CSP受试者中最常被检测到（分别为63%和60%）。与CSP组相比，CLP组中耐甲氧西林金黄色葡萄球菌（MSSA）的检出频率显著更高。在T2时，与CSP相比，CLP婴儿中[具体细菌名称2]、MSSA、[具体细菌名称3]和肠杆菌科成员的百分比显著更高。[具体细菌名称4]和[具体细菌名称5]在舌上出现的频率最高，而[具体细菌名称6]在腭上占主导地位。CLP受试者微生物群的发展特点是病原菌患病率显著增加。
